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Tbio
PSPH
Phosphoserine phosphatase

Protein Summary
Description
Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275605
  • ENSP00000275605
  • ENSG00000146733
  • ENST00000395471
  • ENSP00000378854
  • ENST00000437355
  • ENSP00000401639

Symbol
  • PSP
  • PSPHD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
kinase perturbation
0.81
PubMedID
0.79
small molecule perturbation
0.79
gene perturbation
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.02   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.02   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glycine measurement
3
2
3
92
amino acid measurement
3
2
3
83.8
blood metabolite measurement
2
1
2
77.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glycine measurement
3
92
amino acid measurement
3
83.8
blood metabolite measurement
2
77.3
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Serine biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Serine biosynthesis
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (116)
1 – 10 of 116
PSAT1
Tbio
Family: Enzyme
Novelty: 0.00371113
Score: 0.996
Data Source: STRINGDB
SHMT2
Tbio
Family: Enzyme
Novelty: 0.00234505
Score: 0.984
Data Source: STRINGDB
SHMT1
Tbio
Family: Enzyme
Novelty: 0.00200739
Score: 0.983
Data Source: STRINGDB
SDS
Tbio
Family: Enzyme
Novelty: 0.00482255
Score: 0.956
Data Source: STRINGDB
AGXT
Tbio
Family: Enzyme
Novelty: 0.00267512
Score: 0.952
Data Source: STRINGDB
PHGDH
Tbio
Family: Enzyme
Novelty: 0.00047542
Score: 0.949
Data Source: STRINGDB
SRR
Tbio
Family: Enzyme
Novelty: 0.00425993
Score: 0.938
Data Source: STRINGDB
SDSL
Tbio
Family: Enzyme
Novelty: 0.02098867
Score: 0.934
Data Source: STRINGDB
CBSL
Tdark
Novelty: 0.00062189
Score: 0.931
Data Source: STRINGDB
PPM1K
Tbio
Family: Enzyme
Novelty: 0.0337866
Score: 0.904
Data Source: STRINGDB
Publication Statistics
PubMed Score  83.02

PubMed score by year
PubTator Score  51.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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