PSPH
Phosphoserine phosphatase
Protein Summary
Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008]
- ENST00000275605
- ENSP00000275605
- ENSG00000146733
- ENST00000395471
- ENSP00000378854
- ENST00000437355
- ENSP00000401639
- PSP
- PSPHD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.86 | ||
kinase perturbation | 0.81 | ||
PubMedID | 0.79 | ||
small molecule perturbation | 0.79 | ||
gene perturbation | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 108.49 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 316 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 108.49 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 316 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0