Tchem CYP4F2 Phylloquinone omega-hydroxylase CYP4F2

Protein Summary

Description

Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070). Also acts as a leukotriene-B(4) omega-hydroxylase by mediating conversion of leukotriene-B(4) (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene-B(4) (20-OH LTB4) (PubMed:8026587, PubMed:9799565). This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P78329
• A0A024R7K3
• A8K425
• B4DV75
• Q16677
• Q6NWT4
• Q6NWT6
• Q9NNZ0
• Q9UIU8

Gene Name

• CYP4F2

Ensembl ID

• ENST00000221700
• ENSP00000221700
• ENSG00000186115

Symbol

• CPF2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.92
molecular function	0.91
co-expressed gene	0.82
phenotype	0.8
trait	0.75

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / Phylloquinone Omega-hydroxylase Cyp4f2

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / Phylloquinone Omega-hydroxylase Cyp4f2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.76   (req: < 5)

Gene RIFs: 118   (req: <= 3)

Antibodies: 132   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.76   (req: >= 5)

Gene RIFs: 118   (req: > 3)

Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1