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Tchem
ADAM8
Disintegrin and metalloproteinase domain-containing protein 8

Protein Classes
Protein Summary
Description
Possible involvement in extravasation of leukocytes. This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000415217
  • ENSP00000453855
  • ENSG00000151651
  • ENST00000445355
  • ENSP00000453302
  • ENST00000485491
  • ENSP00000453043

Symbol
  • MS2
  • MS2
  • CD156
  • CD156a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
virus perturbation
0.99
protein domain
0.97
gene perturbation
0.79
disease perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.46   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 395   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.46   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 395   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ADAM metallopeptidase domain 8
100428452
Mouse
MGI:107825
11501
Rat
RGD:1566394
499285
Dog
ADAM metallopeptidase domain 8
VGNC:37587
491699
Cow
ADAM metallopeptidase domain 8
VGNC:25612
519652
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ADAM metallopeptidase domain 8
Mouse
Rat
Dog
ADAM metallopeptidase domain 8
Cow
ADAM metallopeptidase domain 8
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P78325-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Degradation of the extracellular matrix (R-HSA-1474228)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Extracellular matrix organization
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (47)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (160)
1 – 10 of 160
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.954
Data Source: STRINGDB
TNFRSF1B
Tbio
Novelty: 0.0013033
Score: 0.949
Data Source: STRINGDB
ITGAM
Tbio
Novelty: 0.00017521
Score: 0.932
Data Source: STRINGDB
MMP25
Tchem
Family: Enzyme
Novelty: 0.01860638
Score: 0.93
Data Source: STRINGDB
ITGAX
Tbio
Novelty: 0.00040471
Score: 0.929
Data Source: STRINGDB
ADAM10
Tchem
Family: Enzyme
Novelty: 0.00160129
Score: 0.929
Data Source: STRINGDB
CLEC4D
Tbio
Novelty: 0.04119682
Score: 0.928
Data Source: STRINGDB
LILRB2
Tbio
Novelty: 0.00545569
Score: 0.928
Data Source: STRINGDB
BST1
Tbio
Family: Enzyme
Novelty: 0.01329061
Score: 0.924
Data Source: STRINGDB
MGAM
Tclin
Family: Enzyme
Novelty: 0.00045865
Score: 0.919
Data Source: STRINGDB
Publication Statistics
PubMed Score  131.46

PubMed score by year
PubTator Score  71.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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