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Tbio
SIRPA
Tyrosine-protein phosphatase non-receptor type substrate 1

Protein Summary
Description
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356025
  • ENSP00000348307
  • ENSG00000198053
  • ENST00000358771
  • ENSP00000351621
  • ENST00000400068
  • ENSP00000382941
  • ENST00000622179
  • ENSP00000478763

Symbol
  • BIT
  • MFR
  • MYD1
  • PTPNS1
  • SHPS1
  • SIRP
  • BIT
  • MFR
  • P84
  • SIRP
  • MYD-1
  • SHPS1
  • CD172A
  • PTPNS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
transcription factor perturbation
0.91
disease perturbation
0.9
virus perturbation
0.88
transcription factor
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 509.38   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 784   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 509.38   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 784   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
3
5
96.3
platelet count
2
2
2
81.5
platelet crit
2
2
2
66.6
reticulocyte measurement
3
2
3
39.5
reticulocyte count
2
1
2
35.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
96.3
platelet count
2
81.5
platelet crit
2
66.6
reticulocyte measurement
3
39.5
reticulocyte count
2
35.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal regulatory protein alpha
VGNC:54155
458039
Mouse
MGI:108563
19261
Rat
RGD:3449
25528
Dog
signal regulatory protein alpha
609452
Horse
signal regulatory protein alpha
100067339
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal regulatory protein alpha
Mouse
Rat
Dog
signal regulatory protein alpha
Horse
signal regulatory protein alpha
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P78324-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (70)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Cell-Cell communication
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Cell-Cell communication
Hemostasis
Immune System
Innate Immune System
Gene Ontology Terms (46)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (144)
1 – 10 of 144
SIRPG
Tbio
Novelty: 0.10364764
p_int: 1
Score: 0.937
Data Source: BioPlex,STRINGDB
SH2D1B
Tbio
Novelty: 0.01535146
p_int: 0.999999501
p_ni: 4.98e-7
p_wrong: 2e-9
Data Source: BioPlex
CLEC4A
Tbio
Novelty: 0.01821643
p_int: 0.999264314
p_ni: 0.000701069
p_wrong: 0.000034618
Score: 0.255
Data Source: BioPlex,STRINGDB
CD47
Tchem
Novelty: 0.00129086
Score: 0.999
Data Source: Reactome,STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.988
Data Source: Reactome,STRINGDB
PTPN6
Tchem
Family: Enzyme
Novelty: 0.00535749
Score: 0.961
Data Source: Reactome,STRINGDB
ITGAM
Tbio
Novelty: 0.00017521
Score: 0.96
Data Source: STRINGDB
ITGAX
Tbio
Novelty: 0.00040471
Score: 0.959
Data Source: STRINGDB
FYB1
Tbio
Novelty: 0.00247573
Score: 0.936
Data Source: Reactome,STRINGDB
CD300A
Tbio
Novelty: 0.01745189
Score: 0.936
Data Source: STRINGDB
Publication Statistics
PubMed Score  509.38

PubMed score by year
PubTator Score  197.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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