You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
IGBP1
Immunoglobulin-binding protein 1

Protein Summary
Description
Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits. The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342206
  • ENSP00000363661
  • ENSG00000089289
  • ENST00000356413
  • ENSP00000348784

Symbol
  • IBP1
  • IBP1
  • ALPHA-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
virus perturbation
1
biological process
0.87
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.14   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.14   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (143)
1 – 10 of 143
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00655436
Score: 0.998
Data Source: STRINGDB
PPP2CB
Tbio
Family: Enzyme
Novelty: 0.06629168
Score: 0.996
Data Source: STRINGDB
TIPRL
Tbio
Novelty: 0.02626584
Score: 0.978
Data Source: STRINGDB
PPP4C
Tbio
Family: Enzyme
Novelty: 0.003894
Score: 0.972
Data Source: STRINGDB
PPP6C
Tbio
Family: Enzyme
Novelty: 0.00299849
Score: 0.951
Data Source: STRINGDB
RPTOR
Tbio
Novelty: 0.00128955
Score: 0.94
Data Source: STRINGDB
MTOR
Tclin
Family: Kinase
Novelty: 0.00014431
Score: 0.937
Data Source: STRINGDB
MLST8
Tbio
Novelty: 0.00212271
Score: 0.927
Data Source: STRINGDB
PPM1B
Tchem
Family: Enzyme
Novelty: 0.02552183
Score: 0.868
Data Source: STRINGDB
AKT1S1
Tchem
Novelty: 0.00529949
Score: 0.838
Data Source: STRINGDB
Publication Statistics
PubMed Score  221.14

PubMed score by year
PubTator Score  403.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer