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Tbio
RNF4
E3 ubiquitin-protein ligase RNF4

Protein Summary
Description
E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation. The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314289
  • ENSP00000315212
  • ENSG00000063978
  • ENST00000506706
  • ENSP00000424076
  • ENST00000511600
  • ENSP00000426503
  • ENST00000511859
  • ENSP00000426615
  • ENST00000541204
  • ENSP00000446369

Symbol
  • SNURF
  • SLX5
  • SNURF
  • RES4-26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
kinase perturbation
0.91
transcription factor binding site profile
0.86
hub protein
0.85
microRNA
0.84


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.97   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.97   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ring finger protein 4
106998232
Mouse
MGI:1201691
19822
Rat
RGD:3583
29274
Dog
ring finger protein 4
VGNC:53203
610552
Horse
ring finger protein 4
VGNC:51305
100051309
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ring finger protein 4
Mouse
Rat
Dog
ring finger protein 4
Horse
ring finger protein 4
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P78317-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
DNA Double-Strand Break Repair
DNA Repair
Gene Ontology Terms (27)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (379)
1 – 10 of 379
SUMO2
Tbio
Novelty: 0.00366833
Score: 0.994
Data Source: STRINGDB
SUMO1
Tbio
Novelty: 0.00137629
Score: 0.993
Data Source: STRINGDB
UBE2D1
Tbio
Novelty: 0.00865867
Score: 0.974
Data Source: STRINGDB
UBE2N
Tbio
Novelty: 0.00620946
Score: 0.973
Data Source: STRINGDB
MDC1
Tbio
Novelty: 0.00533097
Score: 0.97
Data Source: STRINGDB
UBE2D2
Tbio
Novelty: 0.00603877
Score: 0.969
Data Source: STRINGDB
PIAS4
Tbio
Family: TF
Novelty: 0.01388547
Score: 0.967
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.966
Data Source: STRINGDB
RNF111
Tbio
Family: Enzyme
Novelty: 0.03059486
Score: 0.965
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.963
Data Source: STRINGDB
Publication Statistics
PubMed Score  95.97

PubMed score by year
PubTator Score  54.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer