Tbio SH3BP2 SH3 domain-binding protein 2

Protein Summary

Description

Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism. The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• P78314
• A6NNC2
• B2R5R6
• B4DT04
• D3DVR0
• D6R919
• O00500
• O15373
• P78315
• 3BP-2

Gene Name

• SH3BP2

Ensembl ID

• ENST00000356331
• ENSP00000348685
• ENSG00000087266
• ENST00000435136
• ENSP00000403231
• ENST00000442312
• ENSP00000388152
• ENST00000452765
• ENSP00000409746
• ENST00000503393
• ENSP00000422168
• ENST00000511747
• ENSP00000424846
• ENST00000513020
• ENSP00000424072
• ENST00000515737
• ENSP00000422605

Symbol

• 3BP2
• 3BP2
• CRBM
• CRPM
• 3BP-2
• RES4-23

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.82
transcription factor	0.8
transcription factor perturbation	0.8
small molecule perturbation	0.74
cell line	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.78   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 184   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.78   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0