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Tbio
CXADR
Coxsackievirus and adenovirus receptor

Protein Summary
Description
Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. (Microbial infection) Acts as a receptor for adenovirus type C. (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284878
  • ENSP00000284878
  • ENSG00000154639
  • ENST00000356275
  • ENSP00000348620
  • ENST00000400165
  • ENSP00000383029
  • ENST00000400166
  • ENSP00000383030
  • ENST00000400169
  • ENSP00000383033

Symbol
  • CAR
  • CAR
  • HCAR
  • CAR4/6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.95
gene perturbation
0.93
small molecule perturbation
0.87
microRNA
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 353.22   (req: < 5)
Gene RIFs: 87   (req: <= 3)
Antibodies: 417   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 353.22   (req: >= 5)
Gene RIFs: 87   (req: > 3)
Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
57.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
57.7
Protein Data Bank (16)
1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cell surface interactions at the vascular wall
Hemostasis
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (50)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred by Curator (IC)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (39)
1 – 10 of 39
CYP2S1
Tbio
Novelty: 0.02967417
p_int: 0.881735754
p_ni: 0.118264246
Score: 0.188
Data Source: BioPlex,STRINGDB
TMEM185A
Tdark
Novelty: 0.0262898
p_int: 0.758836655
p_ni: 0.241163345
Score: 0.189
Data Source: BioPlex,STRINGDB
JAML
Tbio
Novelty: 0.05682584
Score: 0.984
Data Source: Reactome,STRINGDB
LNX1
Tbio
Family: Enzyme
Novelty: 0.01555905
Score: 0.699
Data Source: STRINGDB
NR1I3
Tchem
Family: NR
Novelty: 0.00221694
Score: 0.669
Data Source: STRINGDB
AGBL3
Tbio
Family: Enzyme
Novelty: 0.01634546
Score: 0.643
Data Source: STRINGDB
CD59
Tbio
Novelty: 0.0008352
Score: 0.625
Data Source: STRINGDB
LNX2
Tbio
Novelty: 0.03889661
Score: 0.615
Data Source: STRINGDB
CD46
Tbio
Novelty: 0.00098341
Score: 0.59
Data Source: STRINGDB
CD300LF
Tbio
Novelty: 0.01373075
Score: 0.587
Data Source: STRINGDB
Publication Statistics
PubMed Score  353.22

PubMed score by year
PubTator Score  257.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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