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Tchem
PAFAH1B2
Platelet-activating factor acetylhydrolase IB subunit beta

Protein Summary
Description
Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000419197
  • ENSP00000388742
  • ENSG00000168092
  • ENST00000527958
  • ENSP00000435289
  • ENST00000529887
  • ENSP00000434951
  • ENST00000530272
  • ENSP00000431365

Symbol
  • PAFAHB
  • HEL-S-303
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
disease perturbation
0.96
microRNA
0.82
kinase perturbation
0.71
transcription factor binding site profile
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.89   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.89   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (72)
PAFAH1B1
Tbio
Family:  Enzyme
Novelty:  0.00256206
Score:  0.996
Data Source:  Reactome,STRINGDB
PAFAH1B3
Tbio
Family:  Enzyme
Novelty:  0.10517347
Score:  0.99
Data Source:  Reactome,STRINGDB
VLDLR
Tbio
Novelty:  0.00352547
Score:  0.94
Data Source:  STRINGDB
RELN
Tbio
Novelty:  0.005326
Score:  0.929
Data Source:  STRINGDB
DAB1
Tbio
Novelty:  0.08538222
Score:  0.914
Data Source:  STRINGDB
NDEL1
Tbio
Novelty:  0.01241819
Score:  0.906
Data Source:  STRINGDB
PAFAH2
Tbio
Family:  Enzyme
Novelty:  0.19881779
Score:  0.887
Data Source:  STRINGDB
PRRC1
Tdark
Novelty:  0.49313765
Score:  0.869
Data Source:  STRINGDB
FAM98B
Tdark
Novelty:  0.47641513
Score:  0.859
Data Source:  STRINGDB
PLA2G7
Tchem
Family:  Enzyme
Novelty:  0.00270949
Score:  0.856
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
COPI-independent Golgi-to-ER retrograde traffic (R-HSA-6811436)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
Golgi-to-ER retrograde transport
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Name
Explore in Pharos
Explore in Source
COPI-independent Golgi-to-ER retrograde traffic
Golgi-to-ER retrograde transport
Immune System
Innate Immune System
Intra-Golgi and retrograde Golgi-to-ER traffic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
8
13
20
99.8
high density lipoprotein cholesterol measurement
7
8
10
17
98.9
apolipoprotein A 1 measurement
1
6
6
98.6
total cholesterol measurement
2
4
5
93.8
apolipoprotein B measurement
2
4
4
90.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
20
99.8
high density lipoprotein cholesterol measurement
10
17
98.9
apolipoprotein A 1 measurement
6
98.6
total cholesterol measurement
5
93.8
apolipoprotein B measurement
4
90.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
platelet activating factor acetylhydrolase 1b catalytic subunit 2
VGNC:3239
451567
Macaque
platelet activating factor acetylhydrolase 1b catalytic subunit 2
703013
Mouse
MGI:108415
18475
Rat
RGD:620332
64189
Dog
platelet activating factor acetylhydrolase 1b catalytic subunit 2 [Source:HGNC Symbol;Acc:HGNC:8575]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
platelet activating factor acetylhydrolase 1b catalytic subunit 2
Macaque
platelet activating factor acetylhydrolase 1b catalytic subunit 2
Mouse
Rat
Dog
platelet activating factor acetylhydrolase 1b catalytic subunit 2 [Source:HGNC Symbol;Acc:HGNC:8575]
Publication Statistics
PubMed Score 13.89
PubMed score by year
PubTator Score 9.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title