Tchem PAFAH1B2 Platelet-activating factor acetylhydrolase IB subunit beta

Protein Summary

Description

Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• P68402
• A8DPS5
• A8DPS6
• A8DPS7
• E9PEJ5
• E9PLP3
• O00687
• Q29459
• Q6IBR6

Gene Name

• PAFAH1B2

Ensembl ID

• ENST00000419197
• ENSP00000388742
• ENSG00000168092
• ENST00000527958
• ENSP00000435289
• ENST00000529887
• ENSP00000434951
• ENST00000530272
• ENSP00000431365

Symbol

• PAFAHB
• HEL-S-303

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
disease perturbation	0.96
microRNA	0.82
kinase perturbation	0.71
transcription factor binding site profile	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.06   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 235   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.06   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0