Tchem CSNK2A1 Casein kinase II subunit alpha

Protein Summary

Description

Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073). Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. Multiple transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Apr 2018]

Uniprot Accession IDs

• P68400
• B4DYS6
• D3DVV8
• P19138
• P20426
• Q14013
• Q5U065
• CK II alpha

Gene Name

• CSNK2A1

Ensembl ID

• ENST00000217244
• ENSP00000217244
• ENSG00000101266
• ENST00000349736
• ENSP00000339247
• ENST00000400217
• ENSP00000383076
• ENST00000643660
• ENSP00000495248
• ENST00000644003
• ENSP00000495387
• ENST00000645623
• ENSP00000495998
• ENST00000646305
• ENSP00000495902
• ENST00000646477
• ENSP00000495439
• ENST00000646561
• ENSP00000496569
• ENST00000646814
• ENSP00000495422
• ENST00000647348
• ENSP00000495912

Symbol

• CK2A1
• CKII
• Cka1
• Cka2
• CK2A1
• OCNDS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
hub protein	1
virus	1
viral protein	0.98
biological process	0.97

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Ck2 Family / Casein Kinase Ii Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 563.31   (req: < 5)

Gene RIFs: 301   (req: <= 3)

Antibodies: 682   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 563.31   (req: >= 5)

Gene RIFs: 301   (req: > 3)

Antibodies: 682   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 222

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0