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Tclin
TUBB4B
Tubulin beta-4B chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340384
  • ENSP00000341289
  • ENSG00000188229

Symbol
  • TUBB2C
  • Beta2
  • TUBB2
  • LCAEOD
  • TUBB2C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
1
molecular function
0.99
protein domain
0.97
transcription factor binding site profile
0.97


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.96   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.96   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin beta 4B class IVb
VGNC:10119
465170
Mouse
MGI:1915472
227613
Rat
RGD:735101
296554
Dog
tubulin beta 4B class IVb
VGNC:47990
102153202
Cow
tubulin beta 4B class IVb
VGNC:36508
539149
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin beta 4B class IVb
Mouse
Rat
Dog
tubulin beta 4B class IVb
Cow
tubulin beta 4B class IVb
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P68371-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (38)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Carboxyterminal post-translational modifications of tubulin
Cell Cycle
Cell Cycle, Mitotic
Gene Ontology Terms (24)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (321)
1 – 10 of 321
OSTM1
Tbio
Novelty: 0.03033192
p_int: 0.955844869
p_ni: 0.044155131
Data Source: BioPlex
CAPS
Tbio
Novelty: 0.04549022
p_int: 0.913993125
p_ni: 0.086006875
Data Source: BioPlex
CDK13
Tchem
Family: Kinase
Novelty: 0.03084808
p_int: 0.833266168
p_ni: 0.166733832
Score: 0.232
Data Source: BioPlex,STRINGDB
LRP1
Tbio
Novelty: 0.00200788
p_int: 0.820597736
p_ni: 0.179402264
Score: 0.168
Data Source: BioPlex,STRINGDB
TUBA1B
Tchem
Novelty: 0.02465964
Score: 0.999
Data Source: STRINGDB
TUBB
Tclin
Novelty: 0.0038007
Score: 0.998
Data Source: STRINGDB
TUBB2A
Tclin
Novelty: 0.00902924
Score: 0.994
Data Source: STRINGDB
TUBA1A
Tchem
Novelty: 0.01030145
Score: 0.99
Data Source: STRINGDB
TUBA4A
Tchem
Novelty: 0.00820546
Score: 0.989
Data Source: STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.96

PubMed score by year
PubTator Score  56.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer