Protein Summary
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants encoding different isoforms have been found f ...more
- ENST00000248437
- ENSP00000248437
- ENSG00000127824
- ENST00000392088
- ENSP00000375938
- TUBA1
- ALS22
- TUBA1
- H2-ALPHA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 1 | ||
interacting protein | 1 | ||
kinase perturbation | 0.97 | ||
molecular function | 0.94 | ||
protein domain | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 102.55 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 477 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 102.55 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 477 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (0)
Protein-Protein Interactions (414)
TCP11L2
Novelty: 1.78903335
p_int: 0.999952415
p_ni: 0.000047585
Score: 0.645
Data Source: BioPlex,STRINGDB
TXNDC9
Novelty: 0.00309772
p_int: 0.99994678
p_ni: 0.00005322
Score: 0.315
Data Source: BioPlex,STRINGDB
DNAJB11
Novelty: 0.02588745
p_int: 0.987010129
p_ni: 0.012989871
Score: 0.176
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (18)
Upstream (9)
Downstream (9)
1 – 5 of 9
Pathways (40)
Reactome (27)
KEGG (5)
PathwayCommons (1)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | AURKA Activation by TPX2 | ||||
Reactome | Anchoring of the basal body to the plasma membrane | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Centrosome maturation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
AURKA Activation by TPX2 | ||||
Anchoring of the basal body to the plasma membrane | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Centrosome maturation | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (4)
Components (7)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte count | 6 | 3 | 8 | 95.7 | |||||
reticulocyte measurement | 3 | 2 | 5 | 92.7 | |||||
vitamin C measurement | 1 | 1 | 1 | 79.9 | |||||
mean reticulocyte volume | 1 | 2 | 2 | 77.5 | |||||
red blood cell distribution width | 2 | 1 | 2 | 75.3 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte count | 8 | 95.7 | |||||
reticulocyte measurement | 5 | 92.7 | |||||
vitamin C measurement | 1 | 79.9 | |||||
mean reticulocyte volume | 2 | 77.5 | |||||
red blood cell distribution width | 2 | 75.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | tubulin alpha 4a | VGNC:14166 | 470654 | |||||
Macaque | tubulin alpha 4a | 702583 | ||||||
Mouse | MGI:1095410 | 22145 | ||||||
Rat | RGD:1359623 | 316531 | ||||||
Dog | tubulin alpha 4a | 478918 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | tubulin alpha 4a | |||||
Macaque | tubulin alpha 4a | |||||
Mouse | ||||||
Rat | ||||||
Dog | tubulin alpha 4a | |||||
Publication Statistics
PubMed Score 102.55
PubMed score by year
PubTator Score 33.78
PubTator score by year
Related Publications
Text Mined References (92)
GeneRif Annotations (19)
Items per page:
0 of 0
PMID | Year | Title |
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