Tchem TUBA4A Tubulin alpha-4A chain

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Alpha-4a Chain

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Alpha-4a Chain

Protein Summary

Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• P68366
• A8MUB1
• B3KNQ6
• P05215

Gene Name

• TUBA4A

Ensembl ID

• ENST00000248437
• ENSP00000248437
• ENSG00000127824
• ENST00000392088
• ENSP00000375938

Symbol

• TUBA1
• ALS22
• TUBA1
• H2-ALPHA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
interacting protein	1
kinase perturbation	0.97
molecular function	0.94
protein domain	0.92

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.21   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 477   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.21   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 477   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

podophyllotoxin

TUBA4ATchem

IC50 : 6

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	1	1	1		80.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	1		80.9

Reset Zoom  Beta Count   Odds Ratio

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tubulin alpha 4a	VGNC:14166	470654
Macaque	tubulin alpha 4a		702583
Mouse	tubulin, alpha 4A	MGI:1095410	22145
Rat	tubulin, alpha 4A	RGD:1359623	316531
Dog	tubulin alpha 4a		478918

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tubulin alpha 4a
Macaque	tubulin alpha 4a
Mouse	tubulin, alpha 4A
Rat	tubulin, alpha 4A
Dog	tubulin alpha 4a

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-P68366-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (40)

Reactome (27)

KEGG (5)

PathwayCommons (1)

WikiPathways (7)

AURKA Activation by TPX2 (R-HSA-8854518)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	AURKA Activation by TPX2	72 targets	R-HSA-8854518
Reactome	Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Centrosome maturation	81 targets	R-HSA-380287

Name	Explore in Pharos	Explore in Source
AURKA Activation by TPX2	72 targets	R-HSA-8854518
Anchoring of the basal body to the plasma membrane	97 targets	R-HSA-5620912
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Centrosome maturation	81 targets	R-HSA-380287

Gene Ontology Terms (18)

Functions (4)

Components (7)

Processes (7)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
protein kinase binding	Inferred from Physical Interaction (IPI)	ARUK-UCL
GTP binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
structural constituent of cytoskeleton	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
GTPase activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (414)

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1 – 10 of 414

• See Interactions on String-DB

TCP11L2

Tdark

Novelty: 1.78903335

p_int: 0.999952415

p_ni: 0.000047585

Score: 0.645

Data Source: BioPlex,STRINGDB

TXNDC9

Tbio

Novelty: 0.00309772

p_int: 0.99994678

p_ni: 0.00005322

Score: 0.315

Data Source: BioPlex,STRINGDB

CAPS

Tbio

Novelty: 0.04549022

p_int: 0.999744338

p_ni: 0.000255662

Data Source: BioPlex

TTC5

Tbio

Novelty: 0.12127698

p_int: 0.99546699

p_ni: 0.00453301

Data Source: BioPlex

SNX21

Tdark

Novelty: 0.32916633

p_int: 0.993656256

p_ni: 0.006343744

Data Source: BioPlex

GLMP

Tdark

Novelty: 0.10163099

p_int: 0.992569107

p_ni: 0.007430893

Data Source: BioPlex

LRP1

Tbio

Novelty: 0.00200788

p_int: 0.991263675

p_ni: 0.008736325

Data Source: BioPlex

WNT7A

Tbio

Novelty: 0.00421662

p_int: 0.990029617

p_ni: 0.009970383

Data Source: BioPlex

MFAP5

Tbio

Novelty: 0.01839035

p_int: 0.988212327

p_ni: 0.011787673

Data Source: BioPlex

DNAJB11

Tbio

Novelty: 0.02588745

p_int: 0.987010129

p_ni: 0.012989871

Score: 0.176

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  99.21

PubMed score by year

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PubTator Score  33.78

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Acetylation
Alternative splicing
Amyotrophic lateral sclerosis
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
GTP-binding
Methylation
Microtubule

GWAS Trait Find Similar Targets

body mass index