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Tchem
TUBA4A
Tubulin alpha-4A chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants encoding different isoforms have been found f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248437
  • ENSP00000248437
  • ENSG00000127824
  • ENST00000392088
  • ENSP00000375938

Symbol
  • TUBA1
  • ALS22
  • TUBA1
  • H2-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
kinase perturbation
0.97
molecular function
0.94
protein domain
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.21   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 477   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.21   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 477   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
80.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
80.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin alpha 4a
VGNC:14166
470654
Macaque
tubulin alpha 4a
702583
Mouse
MGI:1095410
22145
Rat
RGD:1359623
316531
Dog
tubulin alpha 4a
478918
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin alpha 4a
Macaque
tubulin alpha 4a
Mouse
Rat
Dog
tubulin alpha 4a
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P68366-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (40)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (414)
1 – 10 of 414
TCP11L2
Tdark
Novelty: 1.78903335
p_int: 0.999952415
p_ni: 0.000047585
Score: 0.645
Data Source: BioPlex,STRINGDB
TXNDC9
Tbio
Novelty: 0.00309772
p_int: 0.99994678
p_ni: 0.00005322
Score: 0.315
Data Source: BioPlex,STRINGDB
CAPS
Tbio
Novelty: 0.04549022
p_int: 0.999744338
p_ni: 0.000255662
Data Source: BioPlex
TTC5
Tbio
Novelty: 0.12127698
p_int: 0.99546699
p_ni: 0.00453301
Data Source: BioPlex
SNX21
Tdark
Novelty: 0.32916633
p_int: 0.993656256
p_ni: 0.006343744
Data Source: BioPlex
GLMP
Tdark
Novelty: 0.10163099
p_int: 0.992569107
p_ni: 0.007430893
Data Source: BioPlex
LRP1
Tbio
Novelty: 0.00200788
p_int: 0.991263675
p_ni: 0.008736325
Data Source: BioPlex
WNT7A
Tbio
Novelty: 0.00421662
p_int: 0.990029617
p_ni: 0.009970383
Data Source: BioPlex
MFAP5
Tbio
Novelty: 0.01839035
p_int: 0.988212327
p_ni: 0.011787673
Data Source: BioPlex
DNAJB11
Tbio
Novelty: 0.02588745
p_int: 0.987010129
p_ni: 0.012989871
Score: 0.176
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  99.21

PubMed score by year
PubTator Score  33.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer