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Tbio
ACTA1
Actin, alpha skeletal muscle

Protein Summary
Description
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366684
  • ENSP00000355645
  • ENSG00000143632

Symbol
  • ACTA
  • ACTA
  • ASMA
  • CFTD
  • MPFD
  • NEM1
  • NEM2
  • NEM3
  • SHPM
  • CFTD1
  • CFTDM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
virus perturbation
0.97
PubMedID
0.93
molecular function
0.88
gene perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 827.59   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 1254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 827.59   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 1254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloperoxidase measurement
1
1
1
21.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloperoxidase measurement
1
21.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actin, alpha 1, skeletal muscle
VGNC:32
100609865
Macaque
actin, alpha 1, skeletal muscle
100426612
Mouse
MGI:87902
11459
Rat
RGD:2025
29437
Horse
actin, alpha 1, skeletal muscle
VGNC:15012
100065454
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actin, alpha 1, skeletal muscle
Macaque
actin, alpha 1, skeletal muscle
Mouse
Rat
Horse
actin, alpha 1, skeletal muscle
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P68133-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (17)
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Alzheimer disease-presenilin pathway
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Cytoskeletal regulation by Rho GTPase
PathwayCommons: panther
Huntington disease
PathwayCommons: panther
Inflammation mediated by chemokine and cytokine signaling pathway
Name
Explore in Pharos
Explore in Source
Alzheimer disease-presenilin pathway
Cadherin signaling pathway
Cytoskeletal regulation by Rho GTPase
Huntington disease
Inflammation mediated by chemokine and cytokine signaling pathway
Gene Ontology Terms (28)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (416)
1 – 10 of 416
ACTA2
Tbio
Novelty: 0.00199354
p_int: 1
Data Source: BioPlex
CAP1
Tbio
Family: Enzyme
Novelty: 0.0333464
p_int: 0.999999992
p_wrong: 8e-9
Score: 0.813
Data Source: BioPlex,STRINGDB
ANXA8
Tbio
Novelty: 0.00056216
p_int: 0.999999991
p_ni: 9e-9
Score: 0.638
Data Source: BioPlex,STRINGDB
TLE3
Tbio
Novelty: 0.02641884
p_int: 0.999999975
p_ni: 2.4e-8
Score: 0.192
Data Source: BioPlex,STRINGDB
DMC1
Tbio
Novelty: 0.05445277
p_int: 0.999999973
p_ni: 2.7e-8
Score: 0.333
Data Source: BioPlex,STRINGDB
HIF1A
Tchem
Family: TF
Novelty: 0.00011503
p_int: 0.999999872
p_ni: 1.28e-7
Score: 0.331
Data Source: BioPlex,STRINGDB
NCSTN
Tbio
Novelty: 0.00453935
p_int: 0.999999871
p_ni: 1.29e-7
Score: 0.177
Data Source: BioPlex,STRINGDB
ABTB2
Tdark
Novelty: 0.45729157
p_int: 0.999999465
p_ni: 5.35e-7
Data Source: BioPlex
RSPH6A
Tdark
Novelty: 0.03734897
p_int: 0.999998272
p_ni: 0.000001728
Data Source: BioPlex
PPP1R1A
Tbio
Family: Enzyme
Novelty: 0.01565981
p_int: 0.999997012
p_ni: 0.000002988
Score: 0.234
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  827.59

PubMed score by year
PubTator Score  1046.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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