You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
FKBP1B
Peptidyl-prolyl cis-trans isomerase FKBP1B

Protein Summary
Description
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380986
  • ENSP00000370373
  • ENSG00000119782
  • ENST00000380991
  • ENSP00000370379

Symbol
  • FKBP12.6
  • FKBP1L
  • FKBP9
  • OTK4
  • OTK4
  • FKBP1L
  • PKBP1L
  • PPIase
  • FKBP12.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
small molecule perturbation
0.72
kinase perturbation
0.71
tissue sample
0.69


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162.55   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162.55   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (83)
RYR2
Tclin
Family:  IC
Novelty:  0.00078796
Score:  0.999
Data Source:  STRINGDB
RYR1
Tclin
Family:  IC
Novelty:  0.00077827
Score:  0.992
Data Source:  STRINGDB
RYR3
Tclin
Family:  IC
Novelty:  0.0048487
Score:  0.983
Data Source:  STRINGDB
TRDN
Tbio
Novelty:  0.00501554
Score:  0.972
Data Source:  STRINGDB
ASPH
Tbio
Family:  Enzyme
Novelty:  0.00291455
Score:  0.964
Data Source:  STRINGDB
ACVR1
Tchem
Family:  Kinase
Novelty:  0.00284646
Score:  0.962
Data Source:  STRINGDB
PIN1
Tchem
Family:  Enzyme
Novelty:  0.00957198
Score:  0.947
Data Source:  STRINGDB
NME2
Tbio
Family:  Kinase
Novelty:  0.00257937
Score:  0.892
Data Source:  STRINGDB
MTOR
Tclin
Family:  Kinase
Novelty:  0.00012333
Score:  0.892
Data Source:  STRINGDB
TAGLN3
Tbio
Novelty:  0.01781784
Score:  0.884
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Muscle contraction
Reactome
Stimuli-sensing channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Muscle contraction
Stimuli-sensing channels
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (41)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
5
8
98.6
lymphocyte count
3
4
4
98.3
reticulocyte count
7
4
13
97.4
mean corpuscular volume
1
3
3
94.9
appendicular lean mass
3
3
5
94
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
8
98.6
lymphocyte count
4
98.3
reticulocyte count
13
97.4
mean corpuscular volume
3
94.9
appendicular lean mass
5
94
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FK506 binding protein 1B
VGNC:10650
741549
Mouse
MGI:1336205
14226
Rat
RGD:61835
58950
Dog
FK506 binding protein 1B
VGNC:54305
612965
Horse
FK506 binding protein 1B
VGNC:51312
100071629
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FK506 binding protein 1B
Mouse
Rat
Dog
FK506 binding protein 1B
Horse
FK506 binding protein 1B
Publication Statistics
PubMed Score 162.55
PubMed score by year
PubTator Score 85.71
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title