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Tbio
UBE2L3
Ubiquitin-conjugating enzyme E2 L3

Protein Summary
Description
Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342192
  • ENSP00000344259
  • ENSG00000185651
  • ENST00000458578
  • ENSP00000400906
  • ENST00000545681
  • ENSP00000445931

Symbol
  • UBCE7
  • UBCH7
  • E2-F1
  • L-UBC
  • UBCH7
  • UbcM4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
molecular function
1
virus perturbation
1
co-expressed gene
0.99
kinase perturbation
0.98


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.39   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 419   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.39   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 419   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (183)
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.859615556
p_ni:  0.140384444
Score:  0.978
Data Source:  BioPlex,STRINGDB
UBE3A
Tbio
Family:  Enzyme
Novelty:  0.00149368
Score:  0.957
Data Source:  STRINGDB
CBL
Tbio
Family:  Enzyme
Novelty:  0.00114929
Score:  0.946
Data Source:  STRINGDB
UBE2V2
Tbio
Novelty:  0.01112479
Score:  0.931
Data Source:  STRINGDB
WWP1
Tbio
Family:  Enzyme
Novelty:  0.01407874
Score:  0.914
Data Source:  STRINGDB
ITCH
Tbio
Family:  Enzyme
Novelty:  0.00681861
Score:  0.9
Data Source:  STRINGDB
WWP2
Tbio
Family:  Enzyme
Novelty:  0.01935799
Score:  0.89
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.879
Data Source:  STRINGDB
UBE4B
Tbio
Novelty:  0.01396546
Score:  0.876
Data Source:  STRINGDB
YAP1
Tchem
Novelty:  0.00124225
Score:  0.876
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
E3 ubiquitin ligases ubiquitinate target proteins
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Genetic Interaction (IGI)
ParkinsonsUK-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
10
8
16
97.3
mean corpuscular hemoglobin concentration
4
4
4
97.2
lymphocyte count
3
3
3
96.6
mean corpuscular volume
4
4
4
93.6
red blood cell distribution width
4
3
4
92.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
16
97.3
mean corpuscular hemoglobin concentration
4
97.2
lymphocyte count
3
96.6
mean corpuscular volume
4
93.6
red blood cell distribution width
4
92.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin-conjugating enzyme E2 L3 pseudogene
452921
Macaque
ubiquitin-conjugating enzyme E2 L3 pseudogene
712771
Mouse
MGI:109240
22195
Dog
ubiquitin conjugating enzyme E2 L3
477572
Horse
ubiquitin-conjugating enzyme E2 L3
100058286
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin-conjugating enzyme E2 L3 pseudogene
Macaque
ubiquitin-conjugating enzyme E2 L3 pseudogene
Mouse
Dog
ubiquitin conjugating enzyme E2 L3
Horse
ubiquitin-conjugating enzyme E2 L3
Publication Statistics
PubMed Score 61.39
PubMed score by year
PubTator Score 66.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title