Tbio UBE2L3 Ubiquitin-conjugating enzyme E2 L3

Protein Summary

Description

Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• P68036
• B2R4A7
• B4DDG1
• B4DSZ4
• E7EWS7
• P51966
• P70653
• Q9HAV1

Gene Name

• UBE2L3

Ensembl ID

• ENST00000342192
• ENSP00000344259
• ENSG00000185651
• ENST00000458578
• ENSP00000400906
• ENST00000545681
• ENSP00000445931

Symbol

• UBCE7
• UBCH7
• E2-F1
• L-UBC
• UBCH7
• UbcM4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
molecular function	1
virus perturbation	1
co-expressed gene	0.99
kinase perturbation	0.98

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-conjugating Enzyme E2 L3

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-conjugating Enzyme E2 L3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.44   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 419   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.44   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 419   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0