You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ACTC1
Actin, alpha cardiac muscle 1

Protein Summary
Description
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290378
  • ENSP00000290378
  • ENSG00000159251

Symbol
  • ACTC
  • ACTC
  • ASD5
  • CMD1R
  • CMH11
  • LVNC4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
interacting protein
0.99
molecular function
0.94
PubMedID
0.86
pathway
0.77


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 474.95   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 474.95   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actin, alpha, cardiac muscle 1
VGNC:53503
453307
Macaque
actin, alpha, cardiac muscle 1
697367
Mouse
MGI:87905
11464
Rat
RGD:2026
29275
Dog
actin, alpha, cardiac muscle 1
VGNC:37540
478250
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actin, alpha, cardiac muscle 1
Macaque
actin, alpha, cardiac muscle 1
Mouse
Rat
Dog
actin, alpha, cardiac muscle 1
Pathways (33)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Dilated cardiomyopathy (DCM)
KEGG
Hypertrophic cardiomyopathy (HCM)
KEGG
Cardiac muscle contraction
KEGG
Adrenergic signaling in cardiomyocytes
Name
Explore in Pharos
Explore in Source
Dilated cardiomyopathy (DCM)
Hypertrophic cardiomyopathy (HCM)
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Gene Ontology Terms (31)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (275)
1 – 10 of 275
PHACTR2
Tbio
Family: Enzyme
Novelty: 0.25056698
p_int: 0.989554855
p_ni: 0.010445145
Score: 0.887
Data Source: BioPlex,STRINGDB
ACTB
Tbio
Novelty: 0.00006048
p_int: 0.979447364
p_ni: 0.020552636
Score: 0.984
Data Source: BioPlex,STRINGDB
TMOD3
Tbio
Novelty: 0.04744699
p_int: 0.946626307
p_ni: 0.053373693
Score: 0.835
Data Source: BioPlex,STRINGDB
PFN3
Tdark
Novelty: 0.11291078
p_int: 0.945822438
p_ni: 0.054177562
Score: 0.222
Data Source: BioPlex,STRINGDB
NPB
Tdark
Novelty: 0.00936692
p_int: 0.841877761
p_ni: 0.158122239
Score: 0.171
Data Source: BioPlex,STRINGDB
TWF2
Tbio
Novelty: 0.0419582
p_int: 0.816703586
p_ni: 0.183296414
Score: 0.825
Data Source: BioPlex,STRINGDB
COBL
Tbio
Novelty: 0.01903038
p_int: 0.81179602
p_ni: 0.18820398
Score: 0.726
Data Source: BioPlex,STRINGDB
NDUFA4L2
Tclin
Family: Enzyme
Novelty: 0.09625485
p_int: 0.750102572
p_ni: 0.249897428
Score: 0.285
Data Source: BioPlex,STRINGDB
TPM1
Tbio
Novelty: 0.00261206
Score: 0.997
Data Source: STRINGDB
TPM3
Tbio
Novelty: 0.00108151
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score  474.95

PubMed score by year
PubTator Score  30.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer