ACTC1
Actin, alpha cardiac muscle 1
Protein Summary
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]
- ENST00000290378
- ENSP00000290378
- ENSG00000159251
- ACTC
- ACTC
- ASD5
- CMD1R
- CMH11
- LVNC4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein complex | 1 | ||
interacting protein | 0.99 | ||
molecular function | 0.94 | ||
PubMedID | 0.86 | ||
pathway | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 563.98 (req: < 5)
Gene RIFs: 46 (req: <= 3)
Antibodies: 245 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 563.98 (req: >= 5)
Gene RIFs: 46 (req: > 3)
Antibodies: 245 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0