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Tbio
CSNK2B
Casein kinase II subunit beta

Protein Summary
Description
Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit. This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375865
  • ENSP00000365025
  • ENSG00000204435
  • ENST00000375866
  • ENSP00000365026
  • ENST00000375882
  • ENSP00000365042
  • ENST00000383427
  • ENSP00000372919
  • ENSG00000206406
  • ENST00000383433
  • ENSP00000372925
  • ENST00000400110
  • ENSP00000382980
  • ENST00000412802
  • ENSP00000413469
  • ENSG00000224774
  • ENST00000418230
  • ENSP00000411322
  • ENSG00000228875
  • ENST00000422567
  • ENSP00000407018
  • ENSG00000224398
  • ENST00000429633
  • ENSP00000409510
  • ENSG00000230700
  • ENST00000431476
  • ENSP00000394855
  • ENST00000436169
  • ENSP00000412520
  • ENST00000443673
  • ENSP00000400188
  • ENST00000448596
  • ENSP00000391038
  • ENSG00000232960
  • ENST00000451917
  • ENSP00000415303
  • ENST00000452985
  • ENSP00000415237
  • ENST00000453234
  • ENSP00000395275
  • ENST00000454382
  • ENSP00000390900
  • ENST00000454511
  • ENSP00000393756
  • ENST00000455161
  • ENSP00000407379
  • ENST00000458330
  • ENSP00000410802

Symbol
  • CK2N
  • G5A
  • G5A
  • CK2B
  • CK2N
  • Ckb1
  • Ckb2
  • CSK2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
hub protein
0.96
kinase perturbation
0.93
drug perturbation
0.87
biological process
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 683.65   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 553   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 683.65   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 553   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0