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Tbio
CSNK2B
Casein kinase II subunit beta

Protein Summary
Description
Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit. This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375865
  • ENSP00000365025
  • ENSG00000204435
  • ENST00000375866
  • ENSP00000365026
  • ENST00000375882
  • ENSP00000365042
  • ENST00000383427
  • ENSP00000372919
  • ENSG00000206406
  • ENST00000383433
  • ENSP00000372925
  • ENST00000400110
  • ENSP00000382980
  • ENST00000412802
  • ENSP00000413469
  • ENSG00000224774
  • ENST00000418230
  • ENSP00000411322
  • ENSG00000228875
  • ENST00000422567
  • ENSP00000407018
  • ENSG00000224398
  • ENST00000429633
  • ENSP00000409510
  • ENSG00000230700
  • ENST00000431476
  • ENSP00000394855
  • ENST00000436169
  • ENSP00000412520
  • ENST00000443673
  • ENSP00000400188
  • ENST00000448596
  • ENSP00000391038
  • ENSG00000232960
  • ENST00000451917
  • ENSP00000415303
  • ENST00000452985
  • ENSP00000415237
  • ENST00000453234
  • ENSP00000395275
  • ENST00000454382
  • ENSP00000390900
  • ENST00000454511
  • ENSP00000393756
  • ENST00000455161
  • ENSP00000407379
  • ENST00000458330
  • ENSP00000410802

Symbol
  • CK2N
  • G5A
  • G5A
  • CK2B
  • CK2N
  • Ckb1
  • Ckb2
  • CSK2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
hub protein
0.96
kinase perturbation
0.93
drug perturbation
0.87
biological process
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 634.06   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 553   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 634.06   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 553   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2.6
73.4
1
1
0
2.6
73.4
1
1
0
2.6
73.4
1
1
0
2.6
73.4
1
1
0
2.6
73.4
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.6
73.4
0
2.6
73.4
0
2.6
73.4
0
2.6
73.4
0
2.6
73.4
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Rat
RGD:619978
81650
Horse
casein kinase 2 beta
100058658
Cow
casein kinase 2 beta
VGNC:53965
539235
Pig
casein kinase 2 beta
397211
Xenopus
casein kinase 2 beta
XB-GENE-487924
448656
Species
Name
OMA
EggNOG
Inparanoid
Rat
Horse
casein kinase 2 beta
Cow
casein kinase 2 beta
Pig
casein kinase 2 beta
Xenopus
casein kinase 2 beta
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P67870-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (57)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 42
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Axon guidance
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Autophagy
Axon guidance
Cell Cycle
Cell Cycle, Mitotic
Cellular responses to external stimuli
Gene Ontology Terms (37)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (263)
1 – 10 of 263
PCGF3
Tbio
Novelty: 0.14226976
p_int: 0.999999976
p_ni: 2.4e-8
Score: 0.53
Data Source: BioPlex,STRINGDB
ZMYND8
Tbio
Family: Epigenetic
Novelty: 0.05352096
p_int: 0.999999862
p_ni: 1.38e-7
Data Source: BioPlex
ORC1
Tbio
Novelty: 0.02913098
p_int: 0.999999766
p_ni: 2.24e-7
p_wrong: 1e-8
Data Source: BioPlex
AUTS2
Tbio
Novelty: 0.01782909
p_int: 0.999999694
p_ni: 2.84e-7
p_wrong: 2.2e-8
Score: 0.93
Data Source: BioPlex,STRINGDB
GPATCH2
Tdark
Novelty: 0.03284393
p_int: 0.999999596
p_ni: 1.1e-8
p_wrong: 3.93e-7
Data Source: BioPlex
FBRS
Tbio
Novelty: 0.13646817
p_int: 0.99999936
p_ni: 6.24e-7
p_wrong: 1.5e-8
Data Source: BioPlex
PHRF1
Tbio
Family: Epigenetic
Novelty: 0.05250013
p_int: 0.999999161
p_ni: 8.39e-7
Data Source: BioPlex
RNF111
Tbio
Family: Enzyme
Novelty: 0.03059486
p_int: 0.999998191
p_ni: 0.000001795
p_wrong: 1.4e-8
Data Source: BioPlex
KMT2A
Tchem
Family: Epigenetic
Novelty: 0.00192554
p_int: 0.999998045
p_ni: 0.000001955
Data Source: BioPlex
FBRSL1
Tdark
Novelty: 0.53733998
p_int: 0.999997807
p_ni: 0.00000219
p_wrong: 4e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  634.06

PubMed score by year
PubTator Score  326.07

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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