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Tbio
YBX1
Nuclease-sensitive element-binding protein 1

Protein Summary
Description
Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro. The secreted form acts as an extracellular mitogen and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321358
  • ENSP00000361626
  • ENSG00000065978

Symbol
  • NSEP1
  • YB1
  • YB1
  • BP-8
  • CSDB
  • DBPB
  • YB-1
  • CBF-A
  • CSDA2
  • EFI-A
  • NSEP1
  • NSEP-1
  • MDR-NF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
disease perturbation
0.99
ligand (protein) perturbation
0.99
transcription factor perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 863.57   (req: < 5)
Gene RIFs: 250   (req: <= 3)
Antibodies: 504   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 863.57   (req: >= 5)
Gene RIFs: 250   (req: > 3)
Antibodies: 504   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
NOTCH3 Activation and Transmission of Signal to the Nucleus
Reactome
Noncanonical activation of NOTCH3
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
NOTCH3 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
Processing of Capped Intron-Containing Pre-mRNA
Signal Transduction
Gene Ontology Terms (30)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (423)
1 – 10 of 423
RRS1
Tbio
Novelty: 0.01643671
p_int: 0.99310624
p_ni: 0.00689376
Score: 0.286
Data Source: BioPlex,STRINGDB
RNF151
Tdark
Novelty: 2.0077961
p_int: 0.960169455
p_ni: 0.039830545
Data Source: BioPlex
ZC3HAV1
Tbio
Novelty: 0.01357759
p_int: 0.949613931
p_ni: 0.050386069
Score: 0.244
Data Source: BioPlex,STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
p_int: 0.936135517
p_ni: 0.063864483
Score: 0.239
Data Source: BioPlex,STRINGDB
THAP3
Tdark
Family: TF
Novelty: 0.52942342
p_int: 0.919063909
p_ni: 0.080936091
Data Source: BioPlex
BHLHA15
Tbio
Family: TF
Novelty: 0.02721846
p_int: 0.915780006
p_ni: 0.084219994
Data Source: BioPlex
E4F1
Tbio
Family: TF
Novelty: 0.02192338
p_int: 0.907675867
p_ni: 0.092324133
Data Source: BioPlex
LARP4B
Tbio
Novelty: 0.11363794
p_int: 0.896773165
p_ni: 0.103226835
Score: 0.194
Data Source: BioPlex,STRINGDB
RPL7A
Tbio
Novelty: 0.01674027
p_int: 0.895157758
p_ni: 0.104842242
Score: 0.435
Data Source: BioPlex,STRINGDB
ZCRB1
Tdark
Novelty: 0.37592387
p_int: 0.892336467
p_ni: 0.107663533
Score: 0.966
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  863.57

PubMed score by year
PubTator Score  453.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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