Tclin TNNC1 Troponin C, slow skeletal and cardiac muscles

Protein Summary

Description

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• P63316
• O14800
• P02590
• P04463
• TN-C

Gene Name

• TNNC1

Ensembl ID

• ENST00000232975
• ENSP00000232975
• ENSG00000114854

Symbol

• TNNC
• TNC
• TN-C
• TNNC
• CMD1Z
• CMH13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.79
gene perturbation	0.7
PubMedID	0.69
molecular function	0.63
small molecule perturbation	0.61

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Troponin C, Slow Skeletal And Cardiac Muscles

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Troponin C, Slow Skeletal And Cardiac Muscles

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Troponin C, Slow Skeletal And Cardiac Muscles

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.05   (req: < 5)

Gene RIFs: 72   (req: <= 3)

Antibodies: 387   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.05   (req: >= 5)

Gene RIFs: 72   (req: > 3)

Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1