Tbio UBE2I SUMO-conjugating enzyme UBC9

Protein Summary

Description

Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P63279
• D3DU69
• P50550
• Q15698
• Q59GX1
• Q86VB3

Gene Name

• UBE2I

Ensembl ID

• ENST00000325437
• ENSP00000324897
• ENSG00000103275
• ENST00000355803
• ENSP00000348056
• ENST00000397514
• ENSP00000380649
• ENST00000397515
• ENSP00000380650
• ENST00000403747
• ENSP00000385009
• ENST00000406620
• ENSP00000384568
• ENST00000566587
• ENSP00000457064

Symbol

• UBC9
• UBCE9
• P18
• UBC9
• C358B7.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
molecular function	1
disease perturbation	0.99
kinase perturbation	0.99
transcription factor perturbation	0.99

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 430.84   (req: < 5)

Gene RIFs: 120   (req: <= 3)

Antibodies: 476   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 430.84   (req: >= 5)

Gene RIFs: 120   (req: > 3)

Antibodies: 476   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0