UBE2I
SUMO-conjugating enzyme UBC9
Protein Summary
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000325437
- ENSP00000324897
- ENSG00000103275
- ENST00000355803
- ENSP00000348056
- ENST00000397514
- ENSP00000380649
- ENST00000397515
- ENSP00000380650
- ENST00000403747
- ENSP00000385009
- ENST00000406620
- ENSP00000384568
- ENST00000566587
- ENSP00000457064
- UBC9
- UBCE9
- P18
- UBC9
- C358B7.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 1 | ||
molecular function | 1 | ||
disease perturbation | 0.99 | ||
kinase perturbation | 0.99 | ||
transcription factor perturbation | 0.99 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 381.59 (req: < 5)
Gene RIFs: 108 (req: <= 3)
Antibodies: 476 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 381.59 (req: >= 5)
Gene RIFs: 108 (req: > 3)
Antibodies: 476 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (589)
1 – 10 of 589
UBA2
Novelty: 0.01582807
p_int: 0.999996656
p_ni: 0.000003344
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RANGAP1
Family: Enzyme
Novelty: 0.00917672
p_int: 0.996455403
p_ni: 0.003544597
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SUMO2
Novelty: 0.00366833
p_int: 0.994896147
p_ni: 0.005103853
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SAE1
Novelty: 0.01613881
p_int: 0.994110423
p_ni: 0.005889577
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SUMO3
Novelty: 0.03096465
p_int: 0.987642702
p_ni: 0.012357297
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
RANBP2
Family: Enzyme
Novelty: 0.00484823
p_int: 0.979696179
p_ni: 0.020303821
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
B2M
Novelty: 0.00011248
p_int: 0.973168959
p_ni: 0.026831041
Score: 0.708
Data Source: BioPlex,STRINGDB
NEMP1
Novelty: 0.37603456
p_int: 0.882553252
p_ni: 0.117446748
Score: 0.851
Data Source: BioPlex,STRINGDB
RAN
Family: Enzyme
Novelty: 0.00160888
p_int: 0.828559266
p_ni: 0.171440734
Score: 0.98
Data Source: BioPlex,STRINGDB
RCC1
Novelty: 0.00260884
p_int: 0.815845136
p_ni: 0.184154864
Score: 0.858
Data Source: BioPlex,STRINGDB
Pathways (174)
Reactome (40)
KEGG (4)
PathwayCommons (9)
UniProt (1)
WikiPathways (120)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 40
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | DNA Double Strand Break Response | ||||
Reactome | DNA Double-Strand Break Repair | ||||
Reactome | DNA Repair | ||||
Reactome | Formation of Incision Complex in GG-NER | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
DNA Double Strand Break Response | ||||
DNA Double-Strand Break Repair | ||||
DNA Repair | ||||
Formation of Incision Complex in GG-NER | ||||
Gene Ontology Terms (39)
Functions (12)
Components (12)
Processes (15)
Items per page:
10
1 – 10 of 12
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 2 | 2 | 2 | 71.5 | |||||
myeloid white cell count | 1 | 1 | 1 | 70 | |||||
leukocyte count | 1 | 1 | 1 | 62.1 | |||||
inflammatory biomarker measurement | 1 | 1 | 0 | 50.6 | 56.4 | ||||
reticulocyte measurement | 2 | 1 | 2 | 48.5 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 2 | 71.5 | |||||
myeloid white cell count | 1 | 70 | |||||
leukocyte count | 1 | 62.1 | |||||
inflammatory biomarker measurement | 0 | 50.6 | 56.4 | ||||
reticulocyte measurement | 2 | 48.5 | |||||
Find similar targets by:
UniProt Keyword
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GWAS Trait
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MGI Phenotype
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Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ubiquitin conjugating enzyme E2 I | VGNC:13807 | 749975 | |||||
Mouse | MGI:107365 | 22196 | ||||||
Rat | RGD:3926 | 25573 | ||||||
Dog | ubiquitin conjugating enzyme E2 I | VGNC:54084 | 491332 | |||||
Horse | ubiquitin conjugating enzyme E2 I | VGNC:24720 | 100065385 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ubiquitin conjugating enzyme E2 I | |||||
Mouse | ||||||
Rat | ||||||
Dog | ubiquitin conjugating enzyme E2 I | |||||
Horse | ubiquitin conjugating enzyme E2 I | |||||
Publication Statistics
PubMed Score 381.59
PubMed score by year
PubTator Score 259.62
PubTator score by year