UBE2I
SUMO-conjugating enzyme UBC9
Protein Summary
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000325437
- ENSP00000324897
- ENSG00000103275
- ENST00000355803
- ENSP00000348056
- ENST00000397514
- ENSP00000380649
- ENST00000397515
- ENSP00000380650
- ENST00000403747
- ENSP00000385009
- ENST00000406620
- ENSP00000384568
- ENST00000566587
- ENSP00000457064
- UBC9
- UBCE9
- P18
- UBC9
- C358B7.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 1 | ||
molecular function | 1 | ||
disease perturbation | 0.99 | ||
kinase perturbation | 0.99 | ||
transcription factor perturbation | 0.99 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 377.11 (req: < 5)
Gene RIFs: 108 (req: <= 3)
Antibodies: 476 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 377.11 (req: >= 5)
Gene RIFs: 108 (req: > 3)
Antibodies: 476 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
myeloid white cell count | 1 | 1 | 1 | 71.7 | |||||
neutrophil count | 1 | 1 | 1 | 71.5 | |||||
leukocyte count | 1 | 1 | 1 | 32.6 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
myeloid white cell count | 1 | 71.7 | |||||
neutrophil count | 1 | 71.5 | |||||
leukocyte count | 1 | 32.6 | |||||
Protein Data Bank (28)
1 – 5 of 28
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (174)
Reactome (40)
KEGG (4)
PathwayCommons (9)
UniProt (1)
WikiPathways (120)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 40
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | DNA Double Strand Break Response | ||||
Reactome | DNA Double-Strand Break Repair | ||||
Reactome | DNA Repair | ||||
Reactome | Formation of Incision Complex in GG-NER | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
DNA Double Strand Break Response | ||||
DNA Double-Strand Break Repair | ||||
DNA Repair | ||||
Formation of Incision Complex in GG-NER | ||||
Gene Ontology Terms (39)
Functions (12)
Components (12)
Processes (15)
Items per page:
10
1 – 10 of 12
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (589)
1 – 10 of 589
UBA2
Novelty: 0.01582807
p_int: 0.999996656
p_ni: 0.000003344
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RANGAP1
Family: Enzyme
Novelty: 0.00917672
p_int: 0.996455403
p_ni: 0.003544597
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SUMO2
Novelty: 0.00366833
p_int: 0.994896147
p_ni: 0.005103853
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SAE1
Novelty: 0.01613881
p_int: 0.994110423
p_ni: 0.005889577
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SUMO3
Novelty: 0.03096465
p_int: 0.987642702
p_ni: 0.012357297
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
RANBP2
Family: Enzyme
Novelty: 0.00484823
p_int: 0.979696179
p_ni: 0.020303821
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
B2M
Novelty: 0.00011248
p_int: 0.973168959
p_ni: 0.026831041
Score: 0.708
Data Source: BioPlex,STRINGDB
NEMP1
Novelty: 0.37603456
p_int: 0.882553252
p_ni: 0.117446748
Score: 0.851
Data Source: BioPlex,STRINGDB
RAN
Family: Enzyme
Novelty: 0.00160888
p_int: 0.828559266
p_ni: 0.171440734
Score: 0.98
Data Source: BioPlex,STRINGDB
RCC1
Novelty: 0.00260884
p_int: 0.815845136
p_ni: 0.184154864
Score: 0.858
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 377.11
PubMed score by year
PubTator Score 259.62
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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