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Tbio
UBE2I
SUMO-conjugating enzyme UBC9

Protein Summary
Description
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325437
  • ENSP00000324897
  • ENSG00000103275
  • ENST00000355803
  • ENSP00000348056
  • ENST00000397514
  • ENSP00000380649
  • ENST00000397515
  • ENSP00000380650
  • ENST00000403747
  • ENSP00000385009
  • ENST00000406620
  • ENSP00000384568
  • ENST00000566587
  • ENSP00000457064

Symbol
  • UBC9
  • UBCE9
  • P18
  • UBC9
  • C358B7.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
disease perturbation
0.99
kinase perturbation
0.99
transcription factor perturbation
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.14   (req: < 5)
View Publications
Gene RIFs: 108   (req: <= 3)
View Gene RIFs
Antibodies: 476   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.14   (req: >= 5)
Gene RIFs: 108   (req: > 3)
Antibodies: 476   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (28)
1 – 5 of 28
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (174)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
597 targets
R-HSA-1640170
Reactome
DNA Double Strand Break Response
58 targets
R-HSA-5693606
Reactome
DNA Double-Strand Break Repair
146 targets
R-HSA-5693532
Reactome
DNA Repair
306 targets
R-HSA-73894
Reactome
Formation of Incision Complex in GG-NER
43 targets
R-HSA-5696395
Name
Explore in Pharos
Explore in Source
Cell Cycle
597 targets
R-HSA-1640170
DNA Double Strand Break Response
58 targets
R-HSA-5693606
DNA Double-Strand Break Repair
146 targets
R-HSA-5693532
DNA Repair
306 targets
R-HSA-73894
Formation of Incision Complex in GG-NER
43 targets
R-HSA-5696395
Gene Ontology Terms (39)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
SUMO transferase activity
Inferred from Experiment (EXP)
Reactome
SUMO conjugating enzyme activity
Inferred from Direct Assay (IDA)
BHF-UCL
enzyme binding
Inferred from Physical Interaction (IPI)
UniProtKB
RING-like zinc finger domain binding
Inferred from Physical Interaction (IPI)
UniProtKB
small protein activating enzyme binding
Inferred from Physical Interaction (IPI)
CAFA
transcription factor binding
Inferred from Physical Interaction (IPI)
UniProtKB
RNA binding
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
ATP binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
bHLH transcription factor binding
Inferred from Electronic Annotation (IEA)
Ensembl
HLH domain binding
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (589)
1 – 10 of 589
UBA2
Tbio
Novelty: 0.02816874
p_int: 0.999996656
p_ni: 0.000003344
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RANGAP1
Tbio
Family: Enzyme
Novelty: 0.01406078
p_int: 0.996455403
p_ni: 0.003544597
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SUMO2
Tbio
Novelty: 0.00437464
p_int: 0.994896147
p_ni: 0.005103853
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SAE1
Tbio
Novelty: 0.02519067
p_int: 0.994110423
p_ni: 0.005889577
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SUMO3
Tbio
Novelty: 0.0468487
p_int: 0.987642702
p_ni: 0.012357297
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
RANBP2
Tbio
Family: Enzyme
Novelty: 0.00648364
p_int: 0.979696179
p_ni: 0.020303821
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
B2M
Tbio
Novelty: 0.00012184
p_int: 0.973168959
p_ni: 0.026831041
Score: 0.708
Data Source: BioPlex,STRINGDB
NEMP1
Tdark
Novelty: 0.57142857
p_int: 0.882553252
p_ni: 0.117446748
Score: 0.851
Data Source: BioPlex,STRINGDB
RAN
Tbio
Family: Enzyme
Novelty: 0.00230621
p_int: 0.828559266
p_ni: 0.171440734
Score: 0.98
Data Source: BioPlex,STRINGDB
RCC1
Tbio
Novelty: 0.00361427
p_int: 0.815845136
p_ni: 0.184154864
Score: 0.858
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  300.14

PubMed score by year
PubTator Score  259.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPS
1-70
SPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQN
70-140
RVEYEKRVRAQAKKFAPS
140-158
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS