Tbio UBE2I SUMO-conjugating enzyme UBC9

Protein Summary

Description

Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P63279
• D3DU69
• P50550
• Q15698
• Q59GX1
• Q86VB3

Gene Name

• UBE2I

Ensembl ID

• ENST00000325437
• ENSP00000324897
• ENSG00000103275
• ENST00000355803
• ENSP00000348056
• ENST00000397514
• ENSP00000380649
• ENST00000397515
• ENSP00000380650
• ENST00000403747
• ENSP00000385009
• ENST00000406620
• ENSP00000384568
• ENST00000566587
• ENSP00000457064

Symbol

• UBC9
• UBCE9
• P18
• UBC9
• C358B7.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
molecular function	1
disease perturbation	0.99
kinase perturbation	0.99
transcription factor perturbation	0.99

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 381.59   (req: < 5)

Gene RIFs: 108   (req: <= 3)

Antibodies: 476   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 381.59   (req: >= 5)

Gene RIFs: 108   (req: > 3)

Antibodies: 476   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (589)

Explore Interacting Targets

1 – 10 of 589

• See Interactions on String-DB

UBA2

Tbio

Novelty:  0.01582807

p_int:  0.999996656

p_ni:  0.000003344

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

RANGAP1

Tbio

Family:  Enzyme

Novelty:  0.00917672

p_int:  0.996455403

p_ni:  0.003544597

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

SUMO2

Tbio

Novelty:  0.00366833

p_int:  0.994896147

p_ni:  0.005103853

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

SAE1

Tbio

Novelty:  0.01613881

p_int:  0.994110423

p_ni:  0.005889577

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

SUMO3

Tbio

Novelty:  0.03096465

p_int:  0.987642702

p_ni:  0.012357297

p_wrong:  1e-9

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

RANBP2

Tbio

Family:  Enzyme

Novelty:  0.00484823

p_int:  0.979696179

p_ni:  0.020303821

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

B2M

Tbio

Novelty:  0.00011248

p_int:  0.973168959

p_ni:  0.026831041

Score:  0.708

Data Source:  BioPlex,STRINGDB

NEMP1

Tdark

Novelty:  0.37603456

p_int:  0.882553252

p_ni:  0.117446748

Score:  0.851

Data Source:  BioPlex,STRINGDB

RAN

Tchem

Family:  Enzyme

Novelty:  0.00160888

p_int:  0.828559266

p_ni:  0.171440734

Score:  0.98

Data Source:  BioPlex,STRINGDB

RCC1

Tbio

Novelty:  0.00260884

p_int:  0.815845136

p_ni:  0.184154864

Score:  0.858

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (174)

Reactome (40)

KEGG (4)

PathwayCommons (9)

UniProt (1)

WikiPathways (120)

Cell Cycle (R-HSA-1640170)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	DNA Double Strand Break Response	58 targets	R-HSA-5693606
Reactome	DNA Double-Strand Break Repair	146 targets	R-HSA-5693532
Reactome	DNA Repair	306 targets	R-HSA-73894
Reactome	Formation of Incision Complex in GG-NER	43 targets	R-HSA-5696395

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
DNA Double Strand Break Response	58 targets	R-HSA-5693606
DNA Double-Strand Break Repair	146 targets	R-HSA-5693532
DNA Repair	306 targets	R-HSA-73894
Formation of Incision Complex in GG-NER	43 targets	R-HSA-5696395

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (39)

Functions (12)

Components (12)

Processes (15)

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10

1 – 10 of 12

GO Term	Evidence	Assigned by
SUMO transferase activity	Inferred from Experiment (EXP)	Reactome
SUMO conjugating enzyme activity	Inferred from Direct Assay (IDA)	BHF-UCL
enzyme binding	Inferred from Physical Interaction (IPI)	UniProtKB
RING-like zinc finger domain binding	Inferred from Physical Interaction (IPI)	UniProtKB
small protein activating enzyme binding	Inferred from Physical Interaction (IPI)	CAFA
transcription factor binding	Inferred from Physical Interaction (IPI)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
bHLH transcription factor binding	Inferred from Electronic Annotation (IEA)	Ensembl
HLH domain binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (12)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2	2	2		71.5
myeloid white cell count	EFO_0007988	1	1	1		70
leukocyte count	EFO_0004308	1	1	1		62.1
inflammatory biomarker measurement	EFO_0004872	1	1	0	50.6	56.4
reticulocyte measurement	EFO_0010700	2	1	2		48.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2		71.5
myeloid white cell count	EFO_0007988	1		70
leukocyte count	EFO_0004308	1		62.1
inflammatory biomarker measurement	EFO_0004872	0	50.6	56.4
reticulocyte measurement	EFO_0010700	2		48.5

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UniProt Keyword Find Similar Targets

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3D-structure
Acetylation
ATP-binding
Cell cycle
Cell division
Chromosome partition
Complete proteome
Cytoplasm
Host-virus interaction
Isopeptide bond

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
inflammatory biomarker measurement
leukocyte count
monocyte percentage of leukocytes
myeloid white cell count
neutrophil count
pulse pressure measurement
reticulocyte count
reticulocyte measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
embryo phenotype
hematopoietic system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ubiquitin conjugating enzyme E2 I	VGNC:13807	749975
Mouse	ubiquitin-conjugating enzyme E2I	MGI:107365	22196
Rat	ubiquitin-conjugating enzyme E2I	RGD:3926	25573
Dog	ubiquitin conjugating enzyme E2 I	VGNC:54084	491332
Horse	ubiquitin conjugating enzyme E2 I	VGNC:24720	100065385

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ubiquitin conjugating enzyme E2 I
Mouse	ubiquitin-conjugating enzyme E2I
Rat	ubiquitin-conjugating enzyme E2I
Dog	ubiquitin conjugating enzyme E2 I
Horse	ubiquitin conjugating enzyme E2 I

Publication Statistics

PubMed Score 381.59

PubMed score by year

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PubTator Score 259.62

PubTator score by year

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Related Publications

Text Mined References (239)

GeneRif Annotations (108)

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PMID	Year	Title