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Tbio
SUPT4H1
Transcription elongation factor SPT4

Protein Summary
Description
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225504
  • ENSP00000225504
  • ENSG00000213246
  • ENST00000580947
  • ENSP00000462670

Symbol
  • SPT4H
  • SUPT4H
  • SPT4
  • SPT4H
  • SUPT4H
  • Supt4a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
histone modification site profile
0.88
pathway
0.78
biological process
0.76
kinase perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.8   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.8   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
7
8
98.6
neutrophil count
2
4
4
96.5
myeloperoxidase measurement
2
3
3
95.8
neutrophil percentage of leukocytes
2
4
5
93.4
leukocyte count
2
3
3
93.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
8
98.6
neutrophil count
4
96.5
myeloperoxidase measurement
3
95.8
neutrophil percentage of leukocytes
5
93.4
leukocyte count
3
93.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SPT4 homolog, DSIF elongation factor subunit
VGNC:9668
468422
Mouse
MGI:107416
20922
Rat
RGD:1306372
287608
Dog
SPT4 homolog, DSIF elongation factor subunit
VGNC:46991
609757
Horse
SPT4 homolog, DSIF elongation factor subunit
VGNC:23765
100056960
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SPT4 homolog, DSIF elongation factor subunit
Mouse
Rat
Dog
SPT4 homolog, DSIF elongation factor subunit
Horse
SPT4 homolog, DSIF elongation factor subunit
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P63272-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (93)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Disease
Reactome
Formation of HIV elongation complex in the absence of HIV Tat
Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Reactome
Formation of RNA Pol II elongation complex
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Disease
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of RNA Pol II elongation complex
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (203)
1 – 10 of 203
FGF9
Tbio
Novelty:  0.003428
p_int:  0.890835018
p_ni:  0.007032544
p_wrong:  0.102132438
Score:  0.199
Data Source:  BioPlex,STRINGDB
TMA16
Tdark
Novelty:  0.89810617
p_int:  0.890835018
p_ni:  0.007032544
p_wrong:  0.102132438
Score:  0.188
Data Source:  BioPlex,STRINGDB
DOK4
Tbio
Novelty:  0.06349482
p_int:  0.87699403
p_ni:  0.001249042
p_wrong:  0.121756928
Score:  0.188
Data Source:  BioPlex,STRINGDB
STRIP2
Tbio
Novelty:  0.19321125
p_int:  0.847055953
p_ni:  0.004024612
p_wrong:  0.148919435
Data Source:  BioPlex
PLEKHJ1
Tdark
Novelty:  1.44399298
p_int:  0.822078509
p_ni:  0.003342737
p_wrong:  0.174578754
Data Source:  BioPlex
PAK5
Tchem
Family:  Kinase
Novelty:  0.02138632
p_int:  0.811092772
p_ni:  0.002700864
p_wrong:  0.186206364
Score:  0.189
Data Source:  BioPlex,STRINGDB
POLR2I
Tbio
Family:  Enzyme
Novelty:  0.03100605
Score:  0.999
Data Source:  STRINGDB
SUPT5H
Tbio
Novelty:  0.00775042
Score:  0.999
Data Source:  Reactome,STRINGDB
POLR2F
Tbio
Family:  Enzyme
Novelty:  0.03787683
Score:  0.999
Data Source:  STRINGDB
POLR2A
Tbio
Family:  Enzyme
Novelty:  0.00188323
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  71.80

PubMed score by year
PubTator Score  24.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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