Tbio ACTG2 Actin, gamma-enteric smooth muscle

Protein Summary

Description

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of this gene is formed by removal of two N-terminal peptides.[provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• P63267
• B2R7E7
• B4E315
• D6W5H8
• E9PG30
• P12718
• Q504R1
• Q6FI22

Gene Name

• ACTG2

Ensembl ID

• ENST00000345517
• ENSP00000295137
• ENSG00000163017
• ENST00000409624
• ENSP00000386857
• ENST00000409731
• ENSP00000386929

Symbol

• ACTA3
• ACTL3
• ACTSG
• ACT
• ACTE
• VSCM
• ACTA3
• ACTL3
• ACTSG

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.95
gene perturbation	0.91
PubMedID	0.9
small molecule perturbation	0.85
molecular function	0.73

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Actin And Actin Related Protein / Actin, Gamma-enteric Smooth Muscle

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Actin And Actin Related Protein / Actin, Gamma-enteric Smooth Muscle

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.02   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 257   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.02   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0