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Tbio
ACTG1
Actin, cytoplasmic 2

Protein Summary
Description
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Actin gamma 1, encoded by this gene, is a cytoplasmic actin found in all cell types. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss and also with Baraitser-Winter syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331925
  • ENSP00000331514
  • ENSG00000184009
  • ENST00000573283
  • ENSP00000458435
  • ENST00000575087
  • ENSP00000459124
  • ENST00000575842
  • ENSP00000458162
  • ENST00000576544
  • ENSP00000461672
  • ENST00000615544
  • ENSP00000477968
  • ENST00000644774
  • ENSP00000493648

Symbol
  • ACTG
  • ACT
  • ACTG
  • DFNA20
  • DFNA26
  • HEL-176
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
kinase perturbation
1
interacting protein
0.99
molecular function
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 885.55   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 885.55   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (491)
1 – 10 of 491
CFL1
Tbio
Novelty:  0.00071544
Score:  0.997
Data Source:  STRINGDB
CFL2
Tbio
Novelty:  0.01563343
Score:  0.991
Data Source:  STRINGDB
ACTB
Tbio
Novelty:  0.00006048
Score:  0.988
Data Source:  Reactome,STRINGDB
PFN1
Tbio
Novelty:  0.0048861
Score:  0.984
Data Source:  STRINGDB
WIPF1
Tbio
Novelty:  0.00427982
Score:  0.978
Data Source:  STRINGDB
MRTFA
Tbio
Novelty:  0.00270155
Score:  0.976
Data Source:  Reactome,STRINGDB
WASL
Tbio
Novelty:  0.0029314
Score:  0.974
Data Source:  Reactome,STRINGDB
TMSB4X
Tbio
Novelty:  0.00170605
Score:  0.968
Data Source:  STRINGDB
WAS
Tbio
Novelty:  0.00087362
Score:  0.964
Data Source:  STRINGDB
ARPC3
Tbio
Novelty:  0.02951522
Score:  0.963
Data Source:  STRINGDB
Pathways (58)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHB-mediated forward signaling
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPHB-mediated forward signaling
Fcgamma receptor (FCGR) dependent phagocytosis
Gene Ontology Terms (31)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred by Curator (IC)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
5
5
98.2
heel bone mineral density
3
2
4
83
serum alanine aminotransferase measurement
2
1
1
10.3
80.6
sex hormone-binding globulin measurement
6
2
6
80.5
ganglion cell inner plexiform layer thickness measurement
1
1
1
79.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
5
98.2
heel bone mineral density
4
83
serum alanine aminotransferase measurement
1
10.3
80.6
sex hormone-binding globulin measurement
6
80.5
ganglion cell inner plexiform layer thickness measurement
1
79.5
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:87906
11465
Horse
actin gamma 1
VGNC:51374
100050139
Cow
actin gamma 1
404122
Opossum
actin gamma 1
100025924
Chicken
actin, cytoplasmic 2-like
CGNC:58319
776816
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
actin gamma 1
Cow
actin gamma 1
Opossum
actin gamma 1
Chicken
actin, cytoplasmic 2-like
Publication Statistics
PubMed Score 885.55
PubMed score by year
PubTator Score 171.31
PubTator score by year