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Tchem
KCNJ2
Inward rectifier potassium channel 2

Protein Summary
Description
Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium. Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential wav ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243457
  • ENSP00000243457
  • ENSG00000123700
  • ENST00000535240
  • ENSP00000441848

Symbol
  • IRK1
  • IRK1
  • LQT7
  • SQT3
  • ATFB9
  • HHIRK1
  • KIR2.1
  • HHBIRK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
gene perturbation
0.9
biological process
0.8
cellular component
0.75
histone modification site profile
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.78   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.78   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
4
4
86.7
BMI-adjusted waist-hip ratio
1
4
4
86.2
1
2
0
1.9
75.2
Thyrotoxic periodic paralysis
2
2
0
2
75.2
BMI-adjusted hip circumference
1
2
2
73.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
4
86.7
BMI-adjusted waist-hip ratio
4
86.2
0
1.9
75.2
Thyrotoxic periodic paralysis
0
2
75.2
BMI-adjusted hip circumference
2
73.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily J member 2
VGNC:12318
468312
Macaque
potassium voltage-gated channel subfamily J member 2
574189
Mouse
MGI:104744
16518
Rat
RGD:61968
29712
Dog
potassium voltage-gated channel subfamily J member 2
VGNC:42263
403717
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily J member 2
Macaque
potassium voltage-gated channel subfamily J member 2
Mouse
Rat
Dog
potassium voltage-gated channel subfamily J member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P63252-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Activation of G protein gated Potassium channels (R-HSA-1296041)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Cardiac conduction
Reactome
Classical Kir channels
Reactome
G protein gated Potassium channels
Name
Explore in Pharos
Explore in Source
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Cardiac conduction
Classical Kir channels
G protein gated Potassium channels
Gene Ontology Terms (35)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (121)
1 – 10 of 121
KCNQ1
Tclin
Family:  IC
Novelty:  0.0008956
Score:  0.983
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.954
Data Source:  Reactome,STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.942
Data Source:  Reactome,STRINGDB
KCNJ16
Tbio
Family:  IC
Novelty:  0.01883834
Score:  0.942
Data Source:  Reactome,STRINGDB
GNB2
Tbio
Novelty:  0.08682553
Score:  0.939
Data Source:  Reactome,STRINGDB
KCNJ4
Tchem
Family:  IC
Novelty:  0.0093539
Score:  0.938
Data Source:  Reactome,STRINGDB
GNG2
Tbio
Novelty:  0.04807242
Score:  0.922
Data Source:  STRINGDB
KCNJ10
Tbio
Family:  IC
Novelty:  0.00273462
Score:  0.909
Data Source:  Reactome,STRINGDB
KCNJ12
Tchem
Family:  IC
Novelty:  0.00885141
Score:  0.905
Data Source:  Reactome,STRINGDB
GABBR2
Tclin
Family:  GPCR
Novelty:  0.00739771
Score:  0.905
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  320.78

PubMed score by year
PubTator Score  382.46

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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