Tchem KCNJ2 Inward rectifier potassium channel 2

Protein Summary

Description

Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium. Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P63252
• O15110
• P48049

Gene Name

• KCNJ2

Ensembl ID

• ENST00000243457
• ENSP00000243457
• ENSG00000123700
• ENST00000535240
• ENSP00000441848

Symbol

• IRK1
• IRK1
• LQT7
• SQT3
• ATFB9
• HHIRK1
• KIR2.1
• HHBIRK1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
gene perturbation	0.9
biological process	0.8
cellular component	0.75
histone modification site profile	0.75

Protein Classes

DTO Classes

Protein / Ion Channel / Inward Rectifier-type Potassium Channel Family / Kcnj2 Subfamily / Inward Rectifier Potassium Channel 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 354.63   (req: < 5)

Gene RIFs: 137   (req: <= 3)

Antibodies: 285   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 354.63   (req: >= 5)

Gene RIFs: 137   (req: > 3)

Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0