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Tbio
RACK1
Receptor of activated protein C kinase 1

Protein Summary
Description
Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000512805
  • ENSP00000426909
  • ENSG00000204628

Symbol
  • GNB2L1
  • H12.3
  • HLC-7
  • PIG21
  • GNB2L1
  • Gnb2-rs1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 466.35   (req: < 5)
Gene RIFs: 168   (req: <= 3)
Antibodies: 408   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 466.35   (req: >= 5)
Gene RIFs: 168   (req: > 3)
Antibodies: 408   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (17)
1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (132)
Death Receptor Signalling (R-HSA-73887)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Death Receptor Signalling
Reactome
Regulation of TNFR1 signaling
Reactome
Signal Transduction
Reactome
TNF signaling
Reactome
TNFR1-induced NFkappaB signaling pathway
Name
Explore in Pharos
Explore in Source
Death Receptor Signalling
Regulation of TNFR1 signaling
Signal Transduction
TNF signaling
TNFR1-induced NFkappaB signaling pathway
Gene Ontology Terms (67)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (616)
1 – 10 of 616
WIPI1
Tbio
Novelty: 0.01810583
p_int: 0.999454234
p_ni: 0.000545766
Score: 0.34
Data Source: BioPlex,STRINGDB
HELZ
Tbio
Family: Enzyme
Novelty: 0.0263006
p_int: 0.997405737
p_ni: 0.002594263
Score: 0.224
Data Source: BioPlex,STRINGDB
TNRC6C
Tbio
Novelty: 0.16525674
p_int: 0.997229594
p_ni: 0.002770406
Score: 0.332
Data Source: BioPlex,STRINGDB
LARP4B
Tbio
Novelty: 0.153294
p_int: 0.996888961
p_ni: 0.003111039
Score: 0.614
Data Source: BioPlex,STRINGDB
LARP4
Tbio
Novelty: 0.2173913
p_int: 0.996647058
p_ni: 0.003352942
Score: 0.817
Data Source: BioPlex,STRINGDB
MKI67
Tbio
Novelty: 0.00736165
p_int: 0.912536665
p_ni: 0.087463335
Score: 0.23
Data Source: BioPlex,STRINGDB
ZCCHC3
Tdark
Novelty: 1.71428571
p_int: 0.892531414
p_ni: 0.107468586
Score: 0.389
Data Source: BioPlex,STRINGDB
RPL3
Tbio
Novelty: 0.00906457
Score: 0.999
Data Source: STRINGDB
RPS26
Tbio
Novelty: 0.02200535
Score: 0.999
Data Source: STRINGDB
RPL27A
Tbio
Novelty: 0.04335303
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  466.35

PubMed score by year
PubTator Score  261.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV
1-70
ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKY
70-140
TVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASG
140-210
GKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSK
210-280
AEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR
280-317
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR