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Tbio
RPS21
40S ribosomal protein S21

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms have been described, but their existence has not been verified. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343986
  • ENSP00000345957
  • ENSG00000171858

Symbol
  • S21
  • HLDF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
disease perturbation
0.95
kinase perturbation
0.93
transcription factor perturbation
0.91
transcription factor binding site profile
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.21   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.21   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (418)
RPSA
Tbio
Novelty:  0.00250446
p_int:  0.988959674
p_ni:  0.011040326
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPL6
Tbio
Novelty:  0.01742007
Score:  0.999
Data Source:  STRINGDB
RPL10
Tbio
Novelty:  0.01299391
Score:  0.999
Data Source:  STRINGDB
RPL22
Tbio
Novelty:  0.00473197
Score:  0.999
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.999
Data Source:  STRINGDB
RPS29
Tbio
Novelty:  0.02619305
Score:  0.999
Data Source:  STRINGDB
P62861
Tbio
Novelty:  0.01170009
Score:  0.999
Data Source:  STRINGDB
RPS26
Tbio
Novelty:  0.0183394
Score:  0.999
Data Source:  STRINGDB
RPL26
Tbio
Novelty:  0.02077198
Score:  0.999
Data Source:  STRINGDB
RPL31
Tbio
Novelty:  0.03427872
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
4
0
1.2
92.6
hematocrit
2
3
3
79.5
1
1
0
1.1
77.9
hemoglobin measurement
2
2
3
70.9
lower urinary tract symptom
2
2
0
1.3
63.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
92.6
hematocrit
3
79.5
0
1.1
77.9
hemoglobin measurement
3
70.9
lower urinary tract symptom
0
1.3
63.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
40S ribosomal protein S21
458388
Mouse
MGI:1913731
66481
Rat
Dog
ribosomal protein S21
VGNC:45735
485959
Cow
ribosomal protein S21
VGNC:34134
615178
Species
Name
OMA
EggNOG
Inparanoid
Chimp
40S ribosomal protein S21
Mouse
Rat
Dog
ribosomal protein S21
Cow
ribosomal protein S21
Publication Statistics
PubMed Score 170.21
PubMed score by year
PubTator Score 45.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title