You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GNG5
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370641
  • ENSP00000359675
  • ENSG00000174021
  • ENST00000370645
  • ENSP00000359679

Symbol
  • GNGT5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
pathway
0.91
transcription factor perturbation
0.8
co-expressed gene
0.76
kinase perturbation
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.65   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.65   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit gamma 5
VGNC:12951
456977
Macaque
G protein subunit gamma 5
710548
Mouse
MGI:109164
14707
Rat
RGD:620807
79218
Dog
G protein subunit gamma 5
VGNC:41321
100683432
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit gamma 5
Macaque
G protein subunit gamma 5
Mouse
Rat
Dog
G protein subunit gamma 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P63218-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (110)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 59
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Activation of kainate receptors upon glutamate binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Activation of kainate receptors upon glutamate binding
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (574)
1 – 10 of 574
GNAI3
Tbio
Novelty: 0.03484857
p_int: 0.99995578
p_ni: 0.000044056
p_wrong: 1.64e-7
Score: 0.982
Data Source: BioPlex,STRINGDB
GNAI1
Tbio
Novelty: 0.0488971
p_int: 0.999214675
p_ni: 0.000785325
Score: 0.962
Data Source: BioPlex,STRINGDB
GNA13
Tbio
Novelty: 0.04149138
p_int: 0.996820376
p_ni: 0.00317958
p_wrong: 4.4e-8
Score: 0.952
Data Source: BioPlex,STRINGDB
GNAS
Tbio
Novelty: 0.00284739
p_int: 0.987490755
p_ni: 0.012509235
p_wrong: 1.1e-8
Score: 0.953
Data Source: BioPlex,STRINGDB
CITED1
Tbio
Novelty: 0.01956689
p_int: 0.982564514
p_ni: 0.014247526
p_wrong: 0.00318796
Data Source: BioPlex
GNAI2
Tbio
Novelty: 0.03014729
p_int: 0.93701989
p_ni: 0.062948555
p_wrong: 0.000031555
Score: 0.965
Data Source: BioPlex,STRINGDB
SLC25A41
Tdark
Family: Transporter
Novelty: 1.04918395
p_int: 0.930825393
p_ni: 0.0356591
p_wrong: 0.033515507
Data Source: BioPlex
S1PR1
Tclin
Family: GPCR
Novelty: 0.00162513
p_int: 0.9299486
p_ni: 0.06498903
p_wrong: 0.00506237
Score: 0.909
Data Source: BioPlex,STRINGDB
SLC6A5
Tchem
Family: Transporter
Novelty: 0.00387587
p_int: 0.919084625
p_ni: 0.043788259
p_wrong: 0.037127116
Score: 0.547
Data Source: BioPlex,STRINGDB
GNB2
Tbio
Novelty: 0.08682553
p_int: 0.913478909
p_ni: 0.048707556
p_wrong: 0.037813535
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  6.65

PubMed score by year
PubTator Score  2.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer