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Tbio
GNG5
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370641
  • ENSP00000359675
  • ENSG00000174021
  • ENST00000370645
  • ENSP00000359679

Symbol
  • GNGT5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
pathway
0.91
transcription factor perturbation
0.8
co-expressed gene
0.76
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.52   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.52   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (110)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 59
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Activation of kainate receptors upon glutamate binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Activation of kainate receptors upon glutamate binding
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (574)
1 – 10 of 574
GNAI3
Tbio
Novelty: 0.03936457
p_int: 0.99995578
p_ni: 0.000044056
p_wrong: 1.64e-7
Score: 0.982
Data Source: BioPlex,STRINGDB
GNAI1
Tbio
Novelty: 0.12575547
p_int: 0.999214675
p_ni: 0.000785325
Score: 0.962
Data Source: BioPlex,STRINGDB
GNA13
Tbio
Novelty: 0.05970556
p_int: 0.996820376
p_ni: 0.00317958
p_wrong: 4.4e-8
Score: 0.952
Data Source: BioPlex,STRINGDB
GNAS
Tbio
Novelty: 0.00259764
p_int: 0.987490755
p_ni: 0.012509235
p_wrong: 1.1e-8
Score: 0.953
Data Source: BioPlex,STRINGDB
CITED1
Tbio
Novelty: 0.02087842
p_int: 0.982564514
p_ni: 0.014247526
p_wrong: 0.00318796
Data Source: BioPlex
GNAI2
Tbio
Novelty: 0.04542644
p_int: 0.93701989
p_ni: 0.062948555
p_wrong: 0.000031555
Score: 0.965
Data Source: BioPlex,STRINGDB
SLC25A41
Tdark
Family: Transporter
Novelty: 2.02597403
p_int: 0.930825393
p_ni: 0.0356591
p_wrong: 0.033515507
Data Source: BioPlex
S1PR1
Tclin
Family: GPCR
Novelty: 0.00202384
p_int: 0.9299486
p_ni: 0.06498903
p_wrong: 0.00506237
Score: 0.909
Data Source: BioPlex,STRINGDB
SLC6A5
Tchem
Family: Transporter
Novelty: 0.00491865
p_int: 0.919084625
p_ni: 0.043788259
p_wrong: 0.037127116
Score: 0.547
Data Source: BioPlex,STRINGDB
GNB2
Tbio
Novelty: 0.20536996
p_int: 0.913478909
p_ni: 0.048707556
p_wrong: 0.037813535
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  4.52

PubMed score by year
PubTator Score  2.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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