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Tbio
GNGT1
Guanine nucleotide-binding protein G(T) subunit gamma-T1

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This gene encodes the gamma subunit of transducin, a guanine nucleotide-binding protein (G protein) that is found in rod outer segments. Transducin, also known as GMPase, mediates the activation of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase by rhodopsin. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248572
  • ENSP00000248572
  • ENSG00000127928
  • ENST00000429473
  • ENSP00000388777

Symbol
  • GNG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.79
cellular component
0.58
tissue
0.55
virus perturbation
0.55
biological process
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.35   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.35   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (95)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 63
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Activation of kainate receptors upon glutamate binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Activation of kainate receptors upon glutamate binding
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (993)
1 – 10 of 993
GNB3
Tbio
Novelty: 0.0043523
p_int: 0.999997482
p_ni: 0.000001791
p_wrong: 7.27e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
GNB4
Tbio
Novelty: 0.1530232
p_int: 0.999996337
p_ni: 0.000003663
Score: 0.999
Data Source: BioPlex,STRINGDB
GNB2
Tbio
Novelty: 0.20536996
p_int: 0.999996182
p_ni: 0.000003818
Score: 0.999
Data Source: BioPlex,STRINGDB
GNAQ
Tbio
Novelty: 0.00176666
p_int: 0.999974957
p_ni: 0.000025043
Score: 0.955
Data Source: BioPlex,STRINGDB
GNAS
Tbio
Novelty: 0.00259764
p_int: 0.999842896
p_ni: 0.000157104
Score: 0.96
Data Source: BioPlex,STRINGDB
PDCL
Tbio
Novelty: 0.0035385
p_int: 0.99972663
p_ni: 0.00027337
Score: 0.97
Data Source: BioPlex,STRINGDB
GNB1
Tbio
Novelty: 0.04716243
p_int: 0.999616509
p_ni: 0.000383491
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NDOR1
Tbio
Family: Enzyme
Novelty: 0.15078534
p_int: 0.997658006
p_ni: 0.002341994
Data Source: BioPlex
GNA11
Tbio
Novelty: 0.00156526
p_int: 0.997271418
p_ni: 0.002728582
Score: 0.963
Data Source: BioPlex,STRINGDB
GNA13
Tbio
Novelty: 0.05970556
p_int: 0.988155724
p_ni: 0.011844276
Score: 0.957
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  22.35

PubMed score by year
PubTator Score  6.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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