GNGT1
Guanine nucleotide-binding protein G(T) subunit gamma-T1
Protein Summary
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This gene encodes the gamma subunit of transducin, a guanine nucleotide-binding protein (G protein) that is found in rod outer segments. Transducin, also known as GMPase, mediates the activation of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase by rhodopsin. [provided by RefSeq, Jul 2016]
- ENST00000248572
- ENSP00000248572
- ENSG00000127928
- ENST00000429473
- ENSP00000388777
- GNG1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
pathway | 0.79 | ||
cellular component | 0.58 | ||
tissue | 0.55 | ||
virus perturbation | 0.55 | ||
biological process | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.29 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 75 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.29 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 75 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0