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Tbio
GNGT1
Guanine nucleotide-binding protein G(T) subunit gamma-T1

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This gene encodes the gamma subunit of transducin, a guanine nucleotide-binding protein (G protein) that is found in rod outer segments. Transducin, also known as GMPase, mediates the activation of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase by rhodopsin. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248572
  • ENSP00000248572
  • ENSG00000127928
  • ENST00000429473
  • ENSP00000388777

Symbol
  • GNG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.79
cellular component
0.58
tissue
0.55
virus perturbation
0.55
biological process
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.26   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.26   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
79.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
79.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit gamma transducin 1
VGNC:8683
747170
Macaque
G protein subunit gamma transducin 1
700724
Mouse
MGI:109165
14699
Rat
RGD:1595475
680149
Dog
G protein subunit gamma transducin 1
VGNC:41324
403895
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit gamma transducin 1
Macaque
G protein subunit gamma transducin 1
Mouse
Rat
Dog
G protein subunit gamma transducin 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P63211-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (95)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 63
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Activation of kainate receptors upon glutamate binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Activation of kainate receptors upon glutamate binding
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (993)
1 – 10 of 993
GNB3
Tbio
Novelty: 0.0037117
p_int: 0.999997482
p_ni: 0.000001791
p_wrong: 7.27e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
GNB4
Tbio
Novelty: 0.08250797
p_int: 0.999996337
p_ni: 0.000003663
Score: 0.999
Data Source: BioPlex,STRINGDB
GNB2
Tbio
Novelty: 0.08682553
p_int: 0.999996182
p_ni: 0.000003818
Score: 0.999
Data Source: BioPlex,STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
p_int: 0.999974957
p_ni: 0.000025043
Score: 0.955
Data Source: BioPlex,STRINGDB
GNAS
Tbio
Novelty: 0.00284739
p_int: 0.999842896
p_ni: 0.000157104
Score: 0.96
Data Source: BioPlex,STRINGDB
PDCL
Tbio
Novelty: 0.00317454
p_int: 0.99972663
p_ni: 0.00027337
Score: 0.97
Data Source: BioPlex,STRINGDB
GNB1
Tbio
Novelty: 0.02477955
p_int: 0.999616509
p_ni: 0.000383491
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NDOR1
Tbio
Family: Enzyme
Novelty: 0.07400532
p_int: 0.997658006
p_ni: 0.002341994
Data Source: BioPlex
GNA11
Tbio
Novelty: 0.00128664
p_int: 0.997271418
p_ni: 0.002728582
Score: 0.963
Data Source: BioPlex,STRINGDB
GNA13
Tbio
Novelty: 0.04149138
p_int: 0.988155724
p_ni: 0.011844276
Score: 0.957
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  18.26

PubMed score by year
PubTator Score  6.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer