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Tbio
SKP1
S-phase kinase-associated protein 1

Protein Summary
Description
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353411
  • ENSP00000231487
  • ENSG00000113558
  • ENST00000517625
  • ENSP00000429961
  • ENST00000522552
  • ENSP00000429472
  • ENST00000522855
  • ENSP00000429686

Symbol
  • EMC19
  • OCP2
  • SKP1A
  • TCEB1L
  • OCP2
  • p19A
  • EMC19
  • SKP1A
  • OCP-II
  • TCEB1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
1
transcription factor perturbation
0.99
kinase perturbation
0.98
co-expressed gene
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.1   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 495   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.1   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 495   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
18.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
18.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 2 catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9299]
Mouse
MGI:103575
21402
Rat
RGD:1359648
287280
Dog
S-phase kinase associated protein 1
474682
Horse
S-phase kinase associated protein 1
100062946
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 2 catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9299]
Mouse
Rat
Dog
S-phase kinase associated protein 1
Horse
S-phase kinase associated protein 1
Protein Structure (25 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P63208-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 25
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (192)
APC/C-mediated degradation of cell cycle proteins (R-HSA-174143)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 100
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
C-type lectin receptors (CLRs)
Name
Explore in Pharos
Explore in Source
APC/C-mediated degradation of cell cycle proteins
Activation of NF-kappaB in B cells
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
C-type lectin receptors (CLRs)
Protein-Protein Interactions (641)
1 – 10 of 641
FBXL8
Tdark
Novelty: 0.84091737
p_int: 0.999999997
p_ni: 2e-9
p_wrong: 1e-9
Score: 0.963
Data Source: BioPlex,STRINGDB
PCGF1
Tbio
Novelty: 0.06481661
p_int: 0.999999995
p_ni: 5e-9
Score: 0.972
Data Source: BioPlex,STRINGDB
FBXW9
Tdark
Novelty: 1.16615529
p_int: 0.999999993
p_ni: 7e-9
Score: 0.979
Data Source: BioPlex,STRINGDB
FBXO33
Tdark
Novelty: 0.23409767
p_int: 0.999999993
p_ni: 7e-9
Score: 0.681
Data Source: BioPlex,STRINGDB
FBXO9
Tbio
Novelty: 0.2145394
p_int: 0.999999992
p_ni: 8e-9
Score: 0.988
Data Source: BioPlex,STRINGDB
FBXO5
Tbio
Novelty: 0.01571484
p_int: 0.999999992
p_ni: 6e-9
p_wrong: 2e-9
Score: 0.973
Data Source: BioPlex,Reactome,STRINGDB
KDM2A
Tchem
Family: Epigenetic
Novelty: 0.01990727
p_int: 0.999999986
p_ni: 1.3e-8
Score: 0.987
Data Source: BioPlex,STRINGDB
FBXL4
Tbio
Novelty: 0.04286856
p_int: 0.999999986
p_ni: 1.2e-8
p_wrong: 2e-9
Score: 0.976
Data Source: BioPlex,STRINGDB
FBXW2
Tbio
Novelty: 0.01492058
p_int: 0.999999985
p_ni: 1.3e-8
p_wrong: 2e-9
Score: 0.982
Data Source: BioPlex,STRINGDB
MTUS1
Tbio
Novelty: 0.01066081
p_int: 0.99999998
p_ni: 2e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  548.10

PubMed score by year
PubTator Score  217.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer