SKP1
S-phase kinase-associated protein 1
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
virus perturbation | 1 | ||
transcription factor perturbation | 0.99 | ||
kinase perturbation | 0.98 | ||
co-expressed gene | 0.94 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | APC/C-mediated degradation of cell cycle proteins | ||||
Reactome | Activation of NF-kappaB in B cells | ||||
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | C-type lectin receptors (CLRs) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
APC/C-mediated degradation of cell cycle proteins | ||||
Activation of NF-kappaB in B cells | ||||
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
C-type lectin receptors (CLRs) | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 2 | 3 | 71.6 | |||||
eosinophil percentage of leukocytes | 1 | 2 | 2 | 67.4 | |||||
3 | 2 | 0 | 1.4 | 66.3 | |||||
2 | 2 | 0 | 1.1 | 64.2 | |||||
serum non-albumin protein measurement | 1 | 2 | 2 | 60.4 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
eosinophil count | 3 | 71.6 | |||||
eosinophil percentage of leukocytes | 2 | 67.4 | |||||
0 | 1.4 | 66.3 | |||||
0 | 1.1 | 64.2 | |||||
serum non-albumin protein measurement | 2 | 60.4 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | protein phosphatase 2 catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9299] | |||||||
Mouse | MGI:103575 | 21402 | ||||||
Rat | RGD:1359648 | 287280 | ||||||
Dog | S-phase kinase associated protein 1 | 474682 | ||||||
Horse | S-phase kinase associated protein 1 | 100062946 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | protein phosphatase 2 catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9299] | |||||
Mouse | ||||||
Rat | ||||||
Dog | S-phase kinase associated protein 1 | |||||
Horse | S-phase kinase associated protein 1 | |||||
PMID | Year | Title |
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