You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DYNLT1
Dynein light chain Tctex-type 1

Protein Summary
Description
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein. Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367089
  • ENSP00000356056
  • ENSG00000146425

Symbol
  • TCTEL1
  • TCTEX-1
  • TCTEX1
  • CW-1
  • TCTEL1
  • tctex-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor perturbation
0.91
virus perturbation
0.88
cellular component
0.8
biological process
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (184)
DYNC1H1
Tbio
Novelty:  0.0098543
Score:  0.996
Data Source:  STRINGDB
DYNC1LI2
Tbio
Novelty:  0.17381295
Score:  0.99
Data Source:  STRINGDB
DYNLRB1
Tbio
Novelty:  0.01342103
Score:  0.989
Data Source:  STRINGDB
DYNC1LI1
Tbio
Novelty:  0.02164556
Score:  0.988
Data Source:  STRINGDB
DYNLL1
Tbio
Novelty:  0.00397334
Score:  0.981
Data Source:  STRINGDB
DYNC1I1
Tbio
Novelty:  0.12175372
Score:  0.98
Data Source:  STRINGDB
DYNC1I2
Tbio
Novelty:  0.00228615
Score:  0.973
Data Source:  STRINGDB
DYNLL2
Tbio
Novelty:  0.11209457
Score:  0.959
Data Source:  STRINGDB
WDR34
Tbio
Novelty:  0.05515847
Score:  0.954
Data Source:  STRINGDB
BMPR2
Tchem
Family:  Kinase
Novelty:  0.00155912
Score:  0.952
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein A measurement
1
1
1
79.3
intraocular pressure measurement
1
1
1
53.3
1
1
0
1.1
43
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein A measurement
1
79.3
intraocular pressure measurement
1
53.3
0
1.1
43
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein light chain Tctex-type 1
VGNC:8717
463098
Macaque
dynein light chain Tctex-type 1
106998065
Mouse
MGI:98643
21648
Mouse
MGI:3780996
100040531
Rat
RGD:620261
83462
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein light chain Tctex-type 1
Macaque
dynein light chain Tctex-type 1
Mouse
Mouse
Rat
Publication Statistics
PubMed Score 392.00
PubMed score by year
PubTator Score 136.50
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title