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Tbio
DYNLL1
Dynein light chain 1, cytoplasmic

Protein Summary
Description
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Binds and inhibits the catalytic activity of neuronal nitric oxide synthase. Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity. Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads forme ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242577
  • ENSP00000242577
  • ENSG00000088986
  • ENST00000392508
  • ENSP00000376296
  • ENST00000392509
  • ENSP00000376297
  • ENST00000548342
  • ENSP00000447907
  • ENST00000549989
  • ENSP00000446614

Symbol
  • DLC1
  • DNCL1
  • DNCLC1
  • HDLC1
  • LC8
  • PIN
  • DLC1
  • DLC8
  • LC8a
  • DNCL1
  • hdlc1
  • DNCLC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
0.99
hub protein
0.98
biological process
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.18   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.18   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
1
3
90.9
self reported educational attainment
1
1
1
85.2
reticulocyte count
7
4
8
83.3
mean corpuscular volume
1
1
1
56.4
cognitive function measurement
1
1
1
54.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
90.9
self reported educational attainment
1
85.2
reticulocyte count
8
83.3
mean corpuscular volume
1
56.4
cognitive function measurement
1
54.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein light chain LC8-type 1
VGNC:13058
742676
Macaque
dynein light chain LC8-type 1
702360
Mouse
MGI:1861457
56455
Rat
RGD:619866
58945
Dog
dynein light chain LC8-type 1
VGNC:40150
609233
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein light chain LC8-type 1
Macaque
dynein light chain LC8-type 1
Mouse
Rat
Dog
dynein light chain LC8-type 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P63167-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (62)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 55
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Activation of BH3-only proteins
Reactome
Activation of BIM and translocation to mitochondria
Reactome
Adaptive Immune System
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Activation of BH3-only proteins
Activation of BIM and translocation to mitochondria
Adaptive Immune System
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Gene Ontology Terms (45)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (557)
1 – 10 of 557
DNAL4
Tbio
Novelty: 0.15546154
p_int: 0.999993886
p_ni: 0.000006114
Score: 0.594
Data Source: BioPlex,STRINGDB
LRFN4
Tbio
Novelty: 0.12511571
p_int: 0.99989149
p_ni: 0.00010851
Score: 0.196
Data Source: BioPlex,STRINGDB
RHEX
Tbio
Novelty: 0.20957256
p_int: 0.902347606
p_ni: 0.097652394
Score: 0.209
Data Source: BioPlex,STRINGDB
FAM117B
Tdark
Novelty: 1.06316483
p_int: 0.796056898
p_ni: 0.203943102
Score: 0.221
Data Source: BioPlex,STRINGDB
DYNLL2
Tbio
Novelty: 0.11209457
Score: 0.997
Data Source: Reactome,STRINGDB
DYNC1I1
Tbio
Novelty: 0.12175372
Score: 0.994
Data Source: Reactome,STRINGDB
DYNC1H1
Tbio
Novelty: 0.0098543
Score: 0.993
Data Source: Reactome,STRINGDB
DYNC1I2
Tbio
Novelty: 0.00228615
Score: 0.992
Data Source: Reactome,STRINGDB
DYNLRB1
Tbio
Novelty: 0.01342103
Score: 0.984
Data Source: STRINGDB
DYNLT1
Tbio
Novelty: 0.00336045
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  259.18

PubMed score by year
PubTator Score  926.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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