SNRPN
Small nuclear ribonucleoprotein-associated protein N
Protein Summary
May be involved in tissue-specific alternative RNA processing events. This gene is located within the Prader-Willi Syndrome critical region on chromosome 15 and is imprinted and expressed from the paternal allele. It encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing and may contribute to tissue-specific alternative splicing. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants that initiate at the CpG island-associated imprinting center may be bicistronic and also encode the SNRPN upstream reading frame protein (SNURF) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (SNHG14) may originate from the promoters at this locus and share exons with this gene. Alterations in this region are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi ...more
- ENST00000346403
- ENSP00000306223
- ENSG00000128739
- ENST00000390687
- ENSP00000375105
- ENST00000400097
- ENSP00000382969
- ENST00000400100
- ENSP00000382972
- ENST00000554227
- ENSP00000452342
- ENST00000577565
- ENSP00000463458
- ENST00000642807
- ENSP00000495345
- ENST00000645002
- ENSP00000494831
- HCERN3
- SMN
- SMN
- PWCR
- SM-D
- sm-N
- RT-LI
- HCERN3
- SNRNP-N
- SNURF-SNRPN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 545.03 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 144 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 545.03 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 144 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0