Tchem PPP2R2A Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Protein Summary

Description

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• P63151
• B2RBU8
• B4E1T7
• P50409
• Q00007

Gene Name

• PPP2R2A

Ensembl ID

• ENST00000315985
• ENSP00000325074
• ENSG00000221914
• ENST00000380737
• ENSP00000370113

Symbol

• B55A
• PR52A
• PR55A
• B55ALPHA
• PR55alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
disease perturbation	0.93
kinase perturbation	0.91
transcription factor	0.8
microRNA	0.78

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Protein Phosphatase / Serine/threonine-protein Phosphatase 2a 55 Kda Regulatory Subunit B Alpha Isoform

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Protein Phosphatase / Serine/threonine-protein Phosphatase 2a 55 Kda Regulatory Subunit B Alpha Isoform

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.25   (req: < 5)

Gene RIFs: 53   (req: <= 3)

Antibodies: 199   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.25   (req: >= 5)

Gene RIFs: 53   (req: > 3)

Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0