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Tchem
PPP2R2A
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Protein Summary
Description
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315985
  • ENSP00000325074
  • ENSG00000221914
  • ENST00000380737
  • ENSP00000370113

Symbol
  • B55A
  • PR52A
  • PR55A
  • B55ALPHA
  • PR55alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.93
kinase perturbation
0.91
transcription factor
0.8
microRNA
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.5   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.5   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL444092
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
anthropometric measurement
1
1
0
1.1
16.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
anthropometric measurement
0
1.1
16.1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A/B1/B2 associated events during G2/M transition
Reactome
Cyclin D associated events in G1
Reactome
G1 Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin D associated events in G1
G1 Phase
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (313)
1 – 10 of 313
FOXD4
Tbio
Family: TF
Novelty: 0.11166611
p_int: 0.991326133
p_ni: 0.008673867
Score: 0.602
Data Source: BioPlex,STRINGDB
CCDC9
Tdark
Novelty: 0.73149492
p_int: 0.984044948
p_ni: 0.015955052
Data Source: BioPlex
PPP2R2D
Tbio
Family: Enzyme
Novelty: 0.0658328
p_int: 0.980951946
p_ni: 0.019048054
Score: 0.94
Data Source: BioPlex,STRINGDB
SERTAD4
Tdark
Novelty: 0.70786986
p_int: 0.978043761
p_ni: 0.021956239
Score: 0.748
Data Source: BioPlex,STRINGDB
PPP2R1A
Tbio
Family: Enzyme
Novelty: 0.01134139
p_int: 0.967136599
p_ni: 0.032863401
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
FAM19A3
Tdark
Novelty: 0.37183557
p_int: 0.939184025
p_ni: 0.060815975
Data Source: BioPlex
PTPDC1
Tdark
Family: Enzyme
Novelty: 0.38792241
p_int: 0.870908972
p_ni: 0.129091028
Score: 0.838
Data Source: BioPlex,STRINGDB
IER2
Tbio
Novelty: 0.03864806
p_int: 0.84331147
p_ni: 0.15668853
Score: 0.656
Data Source: BioPlex,STRINGDB
PPP2CB
Tbio
Family: Enzyme
Novelty: 0.0483178
p_int: 0.78159784
p_ni: 0.21840216
Score: 0.997
Data Source: BioPlex,STRINGDB
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00496839
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  60.50

PubMed score by year
PubTator Score  27.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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