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Tbio
UBE2B
Ubiquitin-conjugating enzyme E2 B

Protein Summary
Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265339
  • ENSP00000265339
  • ENSG00000119048

Symbol
  • RAD6B
  • HR6B
  • UBC2
  • HHR6B
  • RAD6B
  • E2-17kDa
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
1
biological process
0.99
disease perturbation
0.96
molecular function
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.55   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.55   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
DNA Damage Bypass
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
DNA Damage Bypass
DNA Repair
Protein-Protein Interactions (420)
1 – 10 of 420
RAD18
Tbio
Family: Enzyme
Novelty: 0.00575302
p_int: 0.999920751
p_ni: 0.000079249
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RNF20
Tbio
Family: Enzyme
Novelty: 0.0151325
p_int: 0.958298548
p_ni: 0.041701452
Score: 0.994
Data Source: BioPlex,STRINGDB
UBE2A
Tbio
Novelty: 0.02357865
p_int: 0.891075445
p_ni: 0.108924555
Score: 0.961
Data Source: BioPlex,STRINGDB
UBE2V2
Tbio
Novelty: 0.01761532
Score: 0.996
Data Source: Reactome,STRINGDB
UBR1
Tbio
Family: Enzyme
Novelty: 0.00742688
Score: 0.995
Data Source: STRINGDB
RNF40
Tbio
Family: Enzyme
Novelty: 0.10509531
Score: 0.994
Data Source: STRINGDB
UBR2
Tbio
Family: Enzyme
Novelty: 0.03319944
Score: 0.994
Data Source: STRINGDB
UBE2V1
Tbio
Novelty: 0.03062655
Score: 0.991
Data Source: STRINGDB
SKP1
Tbio
Family: Enzyme
Novelty: 0.00209659
Score: 0.989
Data Source: STRINGDB
UBA1
Tbio
Novelty: 0.00582285
Score: 0.985
Data Source: STRINGDB
Publication Statistics
PubMed Score  41.55

PubMed score by year
PubTator Score  319.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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