YWHAZ
14-3-3 protein zeta/delta
Protein Summary
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
- ENST00000353245
- ENSP00000309503
- ENSG00000164924
- ENST00000395951
- ENSP00000379281
- ENST00000395953
- ENSP00000379283
- ENST00000395956
- ENSP00000379286
- ENST00000395957
- ENSP00000379287
- ENST00000395958
- ENSP00000379288
- ENST00000419477
- ENSP00000395114
- ENST00000457309
- ENSP00000398599
- ENST00000522542
- ENSP00000430072
- HEL4
- YWHAD
- KCIP-1
- HEL-S-3
- HEL-S-93
- 14-3-3-zeta
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
hub protein | 1 | ||
interacting protein | 1 | ||
co-expressed gene | 0.99 | ||
kinase | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 559.53 (req: < 5)
Gene RIFs: 193 (req: <= 3)
Antibodies: 918 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 559.53 (req: >= 5)
Gene RIFs: 193 (req: > 3)
Antibodies: 918 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 14
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0