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Tbio
PPP3R1
Calcineurin subunit B type 1

Protein Summary
Description
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234310
  • ENSP00000234310
  • ENSG00000221823

Symbol
  • CNA2
  • CNB
  • CNB
  • CNB1
  • CALNB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.83
transcription factor binding site profile
0.82
disease perturbation
0.79
hub protein
0.71
small molecule perturbation
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.15   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.15   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lifestyle measurement
1
1
1
61.5
intelligence
2
2
1
5.8
41
potassium measurement
1
1
1
34.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lifestyle measurement
1
61.5
intelligence
1
5.8
41
potassium measurement
1
34.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 3 regulatory subunit B, alpha
100613118
Mouse
MGI:107172
19058
Rat
RGD:69230
29748
Cow
protein phosphatase 3 regulatory subunit B, alpha
VGNC:50247
282321
Platypus
protein phosphatase 3 regulatory subunit B, alpha
100083665
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 3 regulatory subunit B, alpha
Mouse
Rat
Cow
protein phosphatase 3 regulatory subunit B, alpha
Platypus
protein phosphatase 3 regulatory subunit B, alpha
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P63098-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (64)
Activation of BAD and translocation to mitochondria (R-HSA-111447)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BAD and translocation to mitochondria
Reactome
Activation of BH3-only proteins
Reactome
Adaptive Immune System
Reactome
Apoptosis
Reactome
Beta-catenin independent WNT signaling
Name
Explore in Pharos
Explore in Source
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Adaptive Immune System
Apoptosis
Beta-catenin independent WNT signaling
Gene Ontology Terms (14)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (190)
1 – 10 of 190
RCAN3
Tbio
Novelty: 0.12819457
p_int: 0.999999874
p_ni: 1.24e-7
p_wrong: 2e-9
Score: 0.922
Data Source: BioPlex,STRINGDB
RCAN1
Tbio
Novelty: 0.0030009
p_int: 0.99997993
p_ni: 0.000020069
Score: 0.885
Data Source: BioPlex,STRINGDB
PPP3CC
Tbio
Family: Enzyme
Novelty: 0.02633046
p_int: 0.999977927
p_ni: 0.000021914
p_wrong: 1.59e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PPP3CA
Tchem
Family: Enzyme
Novelty: 0.00234189
p_int: 0.999953996
p_ni: 0.000045949
p_wrong: 5.5e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RCAN2
Tbio
Novelty: 0.00174006
p_int: 0.9999415
p_ni: 0.0000585
Score: 0.805
Data Source: BioPlex,STRINGDB
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.999918494
p_ni: 0.000081494
p_wrong: 1.2e-8
Data Source: BioPlex
TNS4
Tbio
Novelty: 0.048713
p_int: 0.999911139
p_ni: 0.000088861
Score: 0.159
Data Source: BioPlex,STRINGDB
TMEM200A
Tdark
Novelty: 0.25580793
p_int: 0.999571073
p_ni: 0.000428891
p_wrong: 3.6e-8
Score: 0.561
Data Source: BioPlex,STRINGDB
GSK3A
Tclin
Family: Kinase
Novelty: 0.00925708
p_int: 0.999175962
p_ni: 0.000824035
p_wrong: 3e-9
Score: 0.254
Data Source: BioPlex,STRINGDB
PDHB
Tbio
Family: Enzyme
Novelty: 0.01018086
p_int: 0.998936616
p_ni: 0.001063344
p_wrong: 4e-8
Score: 0.706
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  358.15

PubMed score by year
PubTator Score  111.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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