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Tbio
GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351004
  • ENSP00000343027
  • ENSG00000127955
  • ENST00000442586
  • ENSP00000391439
  • ENST00000457358
  • ENSP00000410572
  • ENST00000648098
  • ENSP00000497717
  • ENST00000648306
  • ENSP00000497773
  • ENST00000648412
  • ENSP00000497051
  • ENST00000648476
  • ENSP00000497179
  • ENST00000648663
  • ENSP00000497379
  • ENST00000648832
  • ENSP00000497765
  • ENST00000648877
  • ENSP00000497760
  • ENST00000648953
  • ENSP00000496800
  • ENST00000649225
  • ENSP00000496829
  • ENST00000649267
  • ENSP00000497315
  • ENST00000649487
  • ENSP00000498091
  • ENST00000649796
  • ENSP00000497260
  • ENST00000649855
  • ENSP00000497754

Symbol
  • Gi
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
interacting protein
0.93
pathway
0.9
transcription factor perturbation
0.88
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.74   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.74   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (444)
GNAI3
Tbio
Novelty:  0.03484857
p_int:  0.999999997
p_ni:  3e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
GNAO1
Tbio
Novelty:  0.00315097
p_int:  0.999999979
p_ni:  2e-8
Score:  0.957
Data Source:  BioPlex,STRINGDB
RGS12
Tbio
Novelty:  0.02857864
p_int:  0.999999976
p_ni:  3e-9
p_wrong:  2.2e-8
Score:  0.986
Data Source:  BioPlex,STRINGDB
GNAT3
Tbio
Novelty:  0.00702357
p_int:  0.999995297
p_ni:  0.000003713
p_wrong:  9.9e-7
Score:  0.93
Data Source:  BioPlex,STRINGDB
GNG4
Tbio
Novelty:  0.14371438
p_int:  0.999989454
p_ni:  0.000010546
Score:  0.989
Data Source:  BioPlex,STRINGDB
GNB4
Tbio
Novelty:  0.08250797
p_int:  0.999654373
p_ni:  0.000345627
Score:  0.991
Data Source:  BioPlex,STRINGDB
GPSM1
Tbio
Novelty:  0.03510582
p_int:  0.999509008
p_ni:  0.000002631
p_wrong:  0.000488361
Score:  0.99
Data Source:  BioPlex,STRINGDB
GNG5
Tbio
Novelty:  0.1525101
p_int:  0.999214675
p_ni:  0.000785325
Score:  0.962
Data Source:  BioPlex,STRINGDB
MTHFR
Tbio
Family:  Enzyme
Novelty:  0.00018162
p_int:  0.999178559
p_ni:  0.000821441
Data Source:  BioPlex
RGS14
Tbio
Novelty:  0.01986201
p_int:  0.996610103
p_ni:  2.2e-8
p_wrong:  0.003389875
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (48)
Explore Nearest Tclin Targets
Pathways (123)
ADP signalling through P2Y purinoceptor 12 (R-HSA-392170)

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Find Similar Targets
Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of GABAB receptors
Reactome
Adenylate cyclase inhibitory pathway
Reactome
Adrenaline,noradrenaline inhibits insulin secretion
Reactome
Chaperonin-mediated protein folding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 12
Activation of GABAB receptors
Adenylate cyclase inhibitory pathway
Adrenaline,noradrenaline inhibits insulin secretion
Chaperonin-mediated protein folding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
1
2
38.8
sleep duration
1
1
2
38.8
1
1
1
2.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
38.8
sleep duration
2
38.8
1
2.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha i1
VGNC:8681
472425
Mouse
MGI:95771
14677
Rat
RGD:2713
25686
Cow
G protein subunit alpha i1
VGNC:29449
281790
Opossum
G protein subunit alpha i1
100013052
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha i1
Mouse
Rat
Cow
G protein subunit alpha i1
Opossum
G protein subunit alpha i1
Publication Statistics
PubMed Score 16.74
PubMed score by year
PubTator Score 5.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title