Tbio P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Protein Summary

Description

Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161). This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• P63092
• A6NI00
• E1P5G5
• P04895
• Q12927
• Q14433
• Q32P26
• Q5JWD2
• Q5JWD4
• Q5JWD5
• Q6NR75
• Q6NXS0
• Q8TBC0
• Q96H70

Gene Name

• GNAS

Ensembl ID

• ENST00000265620
• ENSP00000265620
• ENSG00000087460
• ENST00000354359
• ENSP00000346328
• ENST00000371085
• ENSP00000360126
• ENST00000371095
• ENSP00000360136

Symbol

• GNAS1
• GSP
• AHO
• GSA
• GSP
• POH
• GPSA
• NESP
• SCG6
• SgVI
• GNAS1
• PITA3
• C20orf45

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
molecular function	1
transcription factor perturbation	1
disease perturbation	0.99
interacting protein	0.99

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1242.78   (req: < 5)

Gene RIFs: 397   (req: <= 3)

Antibodies: 695   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1242.78   (req: >= 5)

Gene RIFs: 397   (req: > 3)

Antibodies: 695   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0