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Tbio
P63092
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161). This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265620
  • ENSP00000265620
  • ENSG00000087460
  • ENST00000354359
  • ENSP00000346328
  • ENST00000371085
  • ENSP00000360126
  • ENST00000371095
  • ENSP00000360136

Symbol
  • GNAS1
  • GSP
  • AHO
  • GSA
  • GSP
  • POH
  • GPSA
  • NESP
  • SCG6
  • SgVI
  • GNAS1
  • PITA3
  • C20orf45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
molecular function
1
transcription factor perturbation
1
disease perturbation
0.99
interacting protein
0.99


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1242.78   (req: < 5)
Gene RIFs: 333   (req: <= 3)
Antibodies: 695   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1242.78   (req: >= 5)
Gene RIFs: 333   (req: > 3)
Antibodies: 695   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (2)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (386)
GNAL
Tbio
Novelty:  0.01757098
p_int:  1
Score:  0.967
Data Source:  BioPlex,STRINGDB
GNG4
Tbio
Novelty:  0.14371438
p_int:  0.999985346
p_ni:  0.000014654
Score:  0.984
Data Source:  BioPlex,STRINGDB
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.999981194
p_ni:  0.000018806
Score:  0.962
Data Source:  BioPlex,Reactome,STRINGDB
TRO
Tbio
Novelty:  0.02850833
p_int:  0.999978679
p_ni:  0.00002132
p_wrong:  1e-9
Data Source:  BioPlex
OCIAD1
Tbio
Novelty:  0.05701069
p_int:  0.999944566
p_ni:  0.000055434
Score:  0.179
Data Source:  BioPlex,STRINGDB
MAGED2
Tbio
Novelty:  0.0134998
p_int:  0.999870889
p_ni:  0.000129111
Score:  0.876
Data Source:  BioPlex,STRINGDB
GNB4
Tbio
Novelty:  0.08250797
p_int:  0.999727486
p_ni:  0.000272514
Score:  0.964
Data Source:  BioPlex,Reactome,STRINGDB
CPT2
Tchem
Family:  Enzyme
Novelty:  0.00345645
p_int:  0.988176583
p_ni:  0.011823417
Score:  0.175
Data Source:  BioPlex,STRINGDB
GNG5
Tbio
Novelty:  0.1525101
p_int:  0.987490755
p_ni:  0.012509235
p_wrong:  1.1e-8
Score:  0.953
Data Source:  BioPlex,STRINGDB
METAP2
Tchem
Family:  Enzyme
Novelty:  0.00570955
p_int:  0.980723479
p_ni:  0.01927627
p_wrong:  2.51e-7
Data Source:  BioPlex
Nearest Tclin Targets (35)
Explore Nearest Tclin Targets
Pathways (98)
Aquaporin-mediated transport (R-HSA-445717)

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Find Similar Targets
Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (i) signalling events
Reactome
G alpha (s) signalling events
Reactome
G alpha (z) signalling events
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Class B/2 (Secretin family receptors)
G alpha (i) signalling events
G alpha (s) signalling events
G alpha (z) signalling events
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (108)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
6
6
24
96.4
blood urea nitrogen measurement
6
6
24
96.4
blood urea nitrogen measurement
6
6
24
96.4
blood urea nitrogen measurement
6
6
24
96.4
body height
1
2
8
90.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
24
96.4
blood urea nitrogen measurement
24
96.4
blood urea nitrogen measurement
24
96.4
blood urea nitrogen measurement
24
96.4
body height
8
90.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 1242.78
PubMed score by year
PubTator Score 1346.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title