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Tbio
P63092
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161). This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265620
  • ENSP00000265620
  • ENSG00000087460
  • ENST00000354359
  • ENSP00000346328
  • ENST00000371085
  • ENSP00000360126
  • ENST00000371095
  • ENSP00000360136

Symbol
  • GNAS1
  • GSP
  • AHO
  • GSA
  • GSP
  • POH
  • GPSA
  • NESP
  • SCG6
  • SgVI
  • GNAS1
  • PITA3
  • C20orf45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
molecular function
1
transcription factor perturbation
1
disease perturbation
0.99
interacting protein
0.99


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1242.78   (req: < 5)
Gene RIFs: 392   (req: <= 3)
Antibodies: 695   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1242.78   (req: >= 5)
Gene RIFs: 392   (req: > 3)
Antibodies: 695   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0