Tbio TRA2B Transformer-2 protein homolog beta

Protein Summary

Description

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• P62995
• B4DVK2
• D3DNU3
• O15449
• Q15815
• Q64283
• TRA-2 beta

Gene Name

• TRA2B

Ensembl ID

• ENST00000342294
• ENSP00000343857
• ENSG00000136527
• ENST00000382191
• ENSP00000371626
• ENST00000453386
• ENSP00000416959
• ENST00000456380
• ENSP00000416887

Symbol

• SFRS10
• SFRS10
• SRFS10
• TRAN2B
• PPP1R156
• TRA2-BETA
• Htra2-beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
co-expressed gene	0.96
transcription factor perturbation	0.96
transcription factor binding site profile	0.94
ligand (protein) perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Transformer-2 Protein Homolog Beta

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Transformer-2 Protein Homolog Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.64   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.64   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0