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Tbio
TRA2B
Transformer-2 protein homolog beta

Protein Summary
Description
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342294
  • ENSP00000343857
  • ENSG00000136527
  • ENST00000382191
  • ENSP00000371626
  • ENST00000453386
  • ENSP00000416959
  • ENST00000456380
  • ENSP00000416887

Symbol
  • SFRS10
  • SFRS10
  • SRFS10
  • TRAN2B
  • PPP1R156
  • TRA2-BETA
  • Htra2-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
co-expressed gene
0.96
transcription factor perturbation
0.96
transcription factor binding site profile
0.94
ligand (protein) perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.57   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.57   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
1
1
1
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
1
70.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transformer 2 beta homolog
574337
Mouse
MGI:106016
20462
Rat
RGD:619886
117259
Dog
transformer 2 beta homolog
VGNC:47759
478663
Horse
transformer 2 beta homolog
VGNC:49264
100067887
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transformer 2 beta homolog
Mouse
Rat
Dog
transformer 2 beta homolog
Horse
transformer 2 beta homolog
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62995-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Protein-Protein Interactions (354)
1 – 10 of 354
TRA2A
Tbio
Novelty: 0.04935993
p_int: 0.982683252
p_ni: 0.017316748
Score: 0.853
Data Source: BioPlex,STRINGDB
SNRNP70
Tbio
Novelty: 0.00116631
p_int: 0.928882649
p_ni: 0.071117351
Score: 0.944
Data Source: BioPlex,STRINGDB
ELAVL2
Tbio
Novelty: 0.00370708
p_int: 0.920610965
p_ni: 0.079389035
Score: 0.923
Data Source: BioPlex,STRINGDB
SNIP1
Tbio
Novelty: 0.01865867
p_int: 0.872731872
p_ni: 0.127268128
Score: 0.638
Data Source: BioPlex,STRINGDB
LUC7L2
Tdark
Novelty: 0.36989457
p_int: 0.838707076
p_ni: 0.161292924
Score: 0.487
Data Source: BioPlex,STRINGDB
U2AF2
Tbio
Novelty: 0.00590935
p_int: 0.813762634
p_ni: 0.186237366
Score: 0.992
Data Source: BioPlex,STRINGDB
NKAPD1
Tdark
Novelty: 1.56979675
p_int: 0.804548095
p_ni: 0.195451905
Data Source: BioPlex
HNRNPA2B1
Tbio
Novelty: 0.00404935
Score: 0.999
Data Source: STRINGDB
SRSF1
Tbio
Novelty: 0.00074446
Score: 0.999
Data Source: STRINGDB
SRSF3
Tbio
Novelty: 0.01015895
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  66.57

PubMed score by year
PubTator Score  37.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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