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Tchem
GRB2
Growth factor receptor-bound protein 2

Protein Summary
Description
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316615
  • ENSP00000317360
  • ENSG00000177885
  • ENST00000316804
  • ENSP00000339007
  • ENST00000392562
  • ENSP00000376345
  • ENST00000392563
  • ENSP00000376346
  • ENST00000392564
  • ENSP00000376347
  • ENST00000648046
  • ENSP00000496913

Symbol
  • ASH
  • ASH
  • Grb3-3
  • MST084
  • NCKAP2
  • MSTP084
  • EGFRBP-GRB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
kinase perturbation
0.98
pathway
0.98


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 943.83   (req: < 5)
Gene RIFs: 127   (req: <= 3)
Antibodies: 633   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 943.83   (req: >= 5)
Gene RIFs: 127   (req: > 3)
Antibodies: 633   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 118
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
49.4
1
1
0
1.1
15.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
49.4
0
1.1
15.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth factor receptor bound protein 2
VGNC:14183
737245
Macaque
growth factor receptor bound protein 2
702041
Mouse
MGI:95805
14784
Rat
RGD:619758
81504
Dog
growth factor receptor bound protein 2
VGNC:41472
483312
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth factor receptor bound protein 2
Macaque
growth factor receptor bound protein 2
Mouse
Rat
Dog
growth factor receptor bound protein 2
Protein Structure (47 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62993-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 47
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (332)
Activated NTRK2 signals through FRS2 and FRS3 (R-HSA-9028731)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 153
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through FRS2 and FRS3
Reactome
Activated NTRK2 signals through PI3K
Reactome
Activated NTRK2 signals through RAS
Reactome
Activated NTRK3 signals through RAS
Reactome
Adaptive Immune System
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through PI3K
Activated NTRK2 signals through RAS
Activated NTRK3 signals through RAS
Adaptive Immune System
Gene Ontology Terms (58)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (588)
1 – 10 of 588
SOS1
Tbio
Novelty: 0.00285343
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SOS2
Tbio
Novelty: 0.01607832
p_int: 1
Score: 0.997
Data Source: BioPlex,STRINGDB
ARAP1
Tbio
Novelty: 0.0479494
p_int: 0.999999998
p_ni: 2e-9
Score: 0.372
Data Source: BioPlex,STRINGDB
CBL
Tbio
Family: Enzyme
Novelty: 0.00114929
p_int: 0.999999997
p_ni: 2e-9
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
WIPF1
Tbio
Novelty: 0.00427982
p_int: 0.999999993
p_ni: 5e-9
p_wrong: 2e-9
Score: 0.787
Data Source: BioPlex,Reactome,STRINGDB
WASL
Tbio
Novelty: 0.0029314
p_int: 0.99999999
p_ni: 1e-8
Score: 0.852
Data Source: BioPlex,Reactome,STRINGDB
WIPF2
Tbio
Novelty: 0.11973409
p_int: 0.99999999
p_ni: 1e-8
Score: 0.601
Data Source: BioPlex,Reactome,STRINGDB
CBLB
Tbio
Family: Enzyme
Novelty: 0.08068177
p_int: 0.999999989
p_ni: 2e-9
p_wrong: 9e-9
Score: 0.895
Data Source: BioPlex,STRINGDB
ASAP1
Tbio
Novelty: 0.00913771
p_int: 0.999999973
p_ni: 1e-8
p_wrong: 1.8e-8
Score: 0.493
Data Source: BioPlex,STRINGDB
PIK3AP1
Tbio
Family: Enzyme
Novelty: 0.11565645
p_int: 0.999999968
p_ni: 5e-9
p_wrong: 2.7e-8
Score: 0.393
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  943.83

PubMed score by year
PubTator Score  767.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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