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Tbio
UBA52
Ubiquitin-60S ribosomal protein L40

Protein Summary
Description
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription fac ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000430157
  • ENSP00000396910
  • ENSG00000221983
  • ENST00000442744
  • ENSP00000388107
  • ENST00000595158
  • ENSP00000471622
  • ENST00000595683
  • ENSP00000470419
  • ENST00000596273
  • ENSP00000471062
  • ENST00000596304
  • ENSP00000472264
  • ENST00000597451
  • ENSP00000473048
  • ENST00000598780
  • ENSP00000472545
  • ENST00000599551
  • ENSP00000470507
  • ENST00000599595
  • ENSP00000471464

Symbol
  • UBCEP2
  • L40
  • CEP52
  • RPL40
  • HUBCEP52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
interacting protein
1
small molecule perturbation
1
hub protein
0.88
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.96   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.96   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0