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Tbio
UBA52
Ubiquitin-60S ribosomal protein L40

Protein Summary
Description
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription fac ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000430157
  • ENSP00000396910
  • ENSG00000221983
  • ENST00000442744
  • ENSP00000388107
  • ENST00000595158
  • ENSP00000471622
  • ENST00000595683
  • ENSP00000470419
  • ENST00000596273
  • ENSP00000471062
  • ENST00000596304
  • ENSP00000472264
  • ENST00000597451
  • ENSP00000473048
  • ENST00000598780
  • ENSP00000472545
  • ENST00000599551
  • ENSP00000470507
  • ENST00000599595
  • ENSP00000471464

Symbol
  • UBCEP2
  • L40
  • CEP52
  • RPL40
  • HUBCEP52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
interacting protein
1
small molecule perturbation
1
hub protein
0.88
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.19   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.19   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (1568)
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
p_int:  0.999999992
p_ni:  6e-9
p_wrong:  2e-9
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.999999959
p_ni:  9e-9
p_wrong:  3.2e-8
Data Source:  BioPlex
SLC13A2
Tbio
Family:  Transporter
Novelty:  0.01020451
p_int:  0.999999926
p_ni:  2.2e-8
p_wrong:  5.2e-8
Score:  0.171
Data Source:  BioPlex,STRINGDB
EIF2B2
Tbio
Novelty:  0.03253919
p_int:  0.999999759
p_ni:  1.57e-7
p_wrong:  8.4e-8
Data Source:  BioPlex
CTAG1A
Tbio
Novelty:  0.00345306
p_int:  0.9999996
p_ni:  4e-7
Data Source:  BioPlex
RNH1
Tbio
Family:  Enzyme
Novelty:  0.00307468
p_int:  0.999998862
p_ni:  0.000001138
Score:  0.26
Data Source:  BioPlex,STRINGDB
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.999998283
p_ni:  0.000001479
p_wrong:  2.38e-7
Data Source:  BioPlex
TMEM141
Tdark
Novelty:  0.62732191
p_int:  0.999992567
p_ni:  0.00000588
p_wrong:  0.000001552
Data Source:  BioPlex
PNPLA5
Tdark
Family:  Enzyme
Novelty:  0.22301215
p_int:  0.999981726
p_ni:  0.000018274
Score:  0.206
Data Source:  BioPlex,STRINGDB
MT1M
Tbio
Novelty:  0.02649699
p_int:  0.99997169
p_ni:  0.00002831
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (350)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 346
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC-Cdc20 mediated degradation of Nek2A
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Cyclin B
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC-Cdc20 mediated degradation of Nek2A
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
2
2
89.7
Oral ulcer
1
1
0
1.1
73
blood metabolite measurement
1
1
1
60.2
creatinine measurement
1
1
1
59.9
reticulocyte measurement
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
89.7
Oral ulcer
0
1.1
73
blood metabolite measurement
1
60.2
creatinine measurement
1
59.9
reticulocyte measurement
1
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
-
Mouse
MGI:98887
22186
Rat
RGD:68344
64156
Dog
ubiquitin A-52 residue ribosomal protein fusion product 1
403722
Horse
ubiquitin A-52 residue ribosomal protein fusion product 1
VGNC:49290
100071005
Species
Name
OMA
EggNOG
Inparanoid
Macaque
-
Mouse
Rat
Dog
ubiquitin A-52 residue ribosomal protein fusion product 1
Horse
ubiquitin A-52 residue ribosomal protein fusion product 1
Publication Statistics
PubMed Score 57.19
PubMed score by year
PubTator Score 34.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title