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Tdark
CACNG7
Voltage-dependent calcium channel gamma-7 subunit

Protein Summary
Description
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2 (PubMed:21172611). The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222212
  • ENSP00000222212
  • ENSG00000105605
  • ENST00000391767
  • ENSP00000375647
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
gene perturbation
0.68
cell type or tissue
0.65
cell line
0.51
metabolite
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.36   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.36   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
89.4
cognitive function measurement
1
1
1
61.5
self reported educational attainment
1
1
1
54.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
89.4
cognitive function measurement
1
61.5
self reported educational attainment
1
54.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit gamma 7
VGNC:10913
749196
Macaque
calcium voltage-gated channel auxiliary subunit gamma 7
720271
Mouse
MGI:1932374
81904
Rat
RGD:628807
140728
Dog
calcium voltage-gated channel auxiliary subunit gamma 7
VGNC:53674
611509
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit gamma 7
Macaque
calcium voltage-gated channel auxiliary subunit gamma 7
Mouse
Rat
Dog
calcium voltage-gated channel auxiliary subunit gamma 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P62955-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (59)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 0 - rapid depolarisation
Reactome
Phase 2 - plateau phase
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 0 - rapid depolarisation
Phase 2 - plateau phase
Protein-Protein Interactions (144)
1 – 10 of 144
CACNB1
Tbio
Family: IC
Novelty: 0.06568749
Score: 0.964
Data Source: STRINGDB
CACNA1D
Tclin
Family: IC
Novelty: 0.00314752
Score: 0.961
Data Source: STRINGDB
CACNA2D1
Tclin
Family: IC
Novelty: 0.01744541
Score: 0.958
Data Source: STRINGDB
CACNG6
Tdark
Family: IC
Novelty: 2.21570926
Score: 0.949
Data Source: STRINGDB
CACNB3
Tbio
Family: IC
Novelty: 0.04007679
Score: 0.945
Data Source: STRINGDB
CACNA2D2
Tclin
Family: IC
Novelty: 0.02041017
Score: 0.944
Data Source: STRINGDB
CACNG3
Tbio
Family: IC
Novelty: 0.32654561
Score: 0.936
Data Source: STRINGDB
CACNG8
Tdark
Family: IC
Novelty: 0.26770379
Score: 0.932
Data Source: STRINGDB
CACNA2D4
Tbio
Family: IC
Novelty: 0.02238343
Score: 0.932
Data Source: STRINGDB
CACNG1
Tbio
Family: IC
Novelty: 0.11899252
Score: 0.93
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.36

PubMed score by year
PubTator Score  2.44

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer