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Tbio
RPL41
60S ribosomal protein L41

Protein Summary
Description
Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000501597
  • ENSP00000420821
  • ENSG00000229117
  • ENST00000546591
  • ENSP00000449026

Symbol
  • L41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
transcription factor binding site profile
0.98
tissue sample
0.72
biological process
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.16   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.16   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
0
1.3
94.4
mathematical ability
4
4
4
94.3
6
5
0
1.1
92.2
body height
2
3
3
91.7
self reported educational attainment
6
4
4
3.4
82
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
94.4
mathematical ability
4
94.3
0
1.1
92.2
body height
3
91.7
self reported educational attainment
4
3.4
82
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62945-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Protein-Protein Interactions (89)
1 – 10 of 89
RPL39
Tbio
Novelty:  0.0307397
Score:  0.966
Data Source:  STRINGDB
RPL6
Tbio
Novelty:  0.01742007
Score:  0.961
Data Source:  STRINGDB
RPL11
Tbio
Novelty:  0.00448962
Score:  0.959
Data Source:  STRINGDB
RPS21
Tbio
Novelty:  0.00578555
Score:  0.954
Data Source:  STRINGDB
RPL31
Tbio
Novelty:  0.03427872
Score:  0.953
Data Source:  STRINGDB
RPL19
Tbio
Novelty:  0.00756385
Score:  0.948
Data Source:  STRINGDB
RPL36A
Tbio
Novelty:  0.06115838
Score:  0.948
Data Source:  STRINGDB
RPL38
Tbio
Novelty:  0.02694553
Score:  0.948
Data Source:  STRINGDB
RPL24
Tbio
Novelty:  0.02160548
Score:  0.947
Data Source:  STRINGDB
RPS29
Tbio
Novelty:  0.02619305
Score:  0.947
Data Source:  STRINGDB
Publication Statistics
PubMed Score  33.16

PubMed score by year
PubTator Score  45.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer