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Tclin
FKBP1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

Protein Classes
Protein Summary
Description
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formati ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381719
  • ENSP00000371138
  • ENSG00000088832
  • ENST00000400137
  • ENSP00000383003

Symbol
  • FKBP1
  • FKBP12
  • FKBP1
  • PKC12
  • PKCI2
  • FKBP12
  • PPIASE
  • FKBP-12
  • FKBP-1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
1
transcription factor perturbation
1
kinase perturbation
0.98
molecular function
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 806.78   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 806.78   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 332
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
1
2
18.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
18.1
Protein Data Bank (49)
1 – 5 of 49
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (30)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Calcineurin activates NFAT
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downstream signaling events of B Cell Receptor (BCR)
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Calcineurin activates NFAT
Disease
Diseases of signal transduction
Downstream signaling events of B Cell Receptor (BCR)
Gene Ontology Terms (40)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Protein-Protein Interactions (206)
1 – 10 of 206
MTOR
Tclin
Family: Kinase
Novelty: 0.00012333
Score: 0.999
Data Source: STRINGDB
TGFBR1
Tchem
Family: Kinase
Novelty: 0.00081645
Score: 0.998
Data Source: Reactome,STRINGDB
PPP3R1
Tbio
Novelty: 0.00263264
Score: 0.997
Data Source: STRINGDB
ACVR1
Tchem
Family: Kinase
Novelty: 0.00284646
Score: 0.992
Data Source: STRINGDB
RYR1
Tclin
Family: IC
Novelty: 0.00077827
Score: 0.985
Data Source: STRINGDB
PPP3CA
Tchem
Family: Enzyme
Novelty: 0.00234189
Score: 0.976
Data Source: STRINGDB
ACVRL1
Tchem
Family: Kinase
Novelty: 0.00310167
Score: 0.961
Data Source: STRINGDB
PIN1
Tchem
Family: Enzyme
Novelty: 0.00957198
Score: 0.955
Data Source: STRINGDB
PPP3CB
Tbio
Family: Enzyme
Novelty: 0.02156713
Score: 0.953
Data Source: STRINGDB
SMAD7
Tbio
Family: TF
Novelty: 0.00116343
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score  806.78

PubMed score by year
PubTator Score  88.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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