Pharos : Target Details

Tclin

Protein Classes

Protein Summary

Description

Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formati ...more

Uniprot Accession IDs

Gene Name

FKBP1A

Ensembl ID

ENST00000381719
ENSP00000371138
ENSG00000088832
ENST00000400137
ENSP00000383003

Symbol

FKBP1
FKBP12
FKBP1
PKC12
PKCI2
FKBP12
PPIASE
FKBP-12
FKBP-1A

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1

disease perturbation	1

transcription factor perturbation	1

kinase perturbation	0.98

molecular function	0.97

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 633.72 (req: < 5)

View Publications

Gene RIFs: 43 (req: <= 3)

View Gene RIFs

Antibodies: 377 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 633.72 (req: >= 5)

Gene RIFs: 43 (req: > 3)

Antibodies: 377 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 332

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5

Explore Approved Drugs

Approved Drugs (5)

1 – 5 of 5

Active Ligands (332)

1 – 10 of 332

Protein Data Bank (49)

1 – 5 of 49

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (30)

Reactome (15)

PathwayCommons (11)

WikiPathways (4)

Adaptive Immune System (R-HSA-1280218)

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Items per page:

1 – 5 of 15

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218

Reactome	Calcineurin activates NFAT	9 targets	R-HSA-2025928

Reactome	Disease	1105 targets	R-HSA-1643685

Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202

Reactome	Downstream signaling events of B Cell Receptor (BCR)	82 targets	R-HSA-1168372

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218

Calcineurin activates NFAT	9 targets	R-HSA-2025928

Disease	1105 targets	R-HSA-1643685

Diseases of signal transduction	387 targets	R-HSA-5663202

Downstream signaling events of B Cell Receptor (BCR)	82 targets	R-HSA-1168372

Gene Ontology Terms (40)

Functions (8)

Components (9)

Processes (23)

Items per page:

1 – 8 of 8

GO Term	Evidence	Assigned by
FK506 binding	Inferred from Direct Assay (IDA)	BHF-UCL

peptidyl-prolyl cis-trans isomerase activity	Inferred from Direct Assay (IDA)	BHF-UCL

activin binding	Inferred from Physical Interaction (IPI)	BHF-UCL

SMAD binding	Inferred from Physical Interaction (IPI)	BHF-UCL

ion channel binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL

transforming growth factor beta receptor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL

type I transforming growth factor beta receptor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL

macrolide binding	Non-traceable Author Statement (NAS)	BHF-UCL

Protein-Protein Interactions (206)

1 – 10 of 206

See Interactions on String-DB

MTOR

Tclin

Family: Kinase

Novelty: 0.00014431

Score: 0.999

Data Source: STRINGDB

TGFBR1

Tchem

Family: Kinase

Novelty: 0.00099344

Score: 0.998

Data Source: Reactome,STRINGDB

PPP3R1

Tbio

Novelty: 0.00213192

Score: 0.997

Data Source: STRINGDB

ACVR1

Tchem

Family: Kinase

Novelty: 0.00312513

Score: 0.992

Data Source: STRINGDB

RYR1

Tclin

Family: IC

Novelty: 0.00089745

Score: 0.985

Data Source: STRINGDB

PPP3CA

Tchem

Family: Enzyme

Novelty: 0.00238194

Score: 0.976

Data Source: STRINGDB

ACVRL1

Tchem

Family: Kinase

Novelty: 0.00374091

Score: 0.961

Data Source: STRINGDB

PIN1

Tchem

Family: Enzyme

Novelty: 0.00170157

Score: 0.955

Data Source: STRINGDB

PPP3CB

Tbio

Family: Enzyme

Novelty: 0.02520885

Score: 0.953

Data Source: STRINGDB

SMAD7

Tbio

Family: TF

Novelty: 0.00137901

Score: 0.947

Data Source: STRINGDB

Publication Statistics

PubMed Score 633.72

PubMed score by year

PubTator Score 88.76

PubTator score by year

Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure

Acetylation

Complete proteome

Cytoplasm

Direct protein sequencing

Isomerase

Membrane

Reference proteome

Rotamase

Sarcoplasmic reticulum

GWAS Trait

MGI Phenotype


behavior/neurological phenotype

cardiovascular system phenotype

cellular phenotype

embryo phenotype

growth/size/body region phenotype

homeostasis/metabolism phenotype

integument phenotype

liver/biliary system phenotype

mortality/aging

muscle phenotype


body mass index

glomerular filtration rate

myeloperoxidase measurement