FKBP1A
Peptidyl-prolyl cis-trans isomerase FKBP1A
Protein Summary
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formati ...more
- ENST00000381719
- ENSP00000371138
- ENSG00000088832
- ENST00000400137
- ENSP00000383003
- FKBP1
- FKBP12
- FKBP1
- PKC12
- PKCI2
- FKBP12
- PPIASE
- FKBP-12
- FKBP-1A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
disease perturbation | 1 | ||
transcription factor perturbation | 1 | ||
kinase perturbation | 0.98 | ||
molecular function | 0.97 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 875.33 (req: < 5)
Gene RIFs: 43 (req: <= 3)
Antibodies: 377 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 875.33 (req: >= 5)
Gene RIFs: 43 (req: > 3)
Antibodies: 377 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 435
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 5
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (5)
Active Ligands (435)
Protein-Protein Interactions (206)
Nearest Tclin Targets
Pathways (30)
Reactome (15)
PathwayCommons (11)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Calcineurin activates NFAT | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | Downstream signaling events of B Cell Receptor (BCR) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Calcineurin activates NFAT | ||||
Disease | ||||
Diseases of signal transduction | ||||
Downstream signaling events of B Cell Receptor (BCR) | ||||
Viral Interactions (0)
Gene Ontology Terms (40)
Functions (8)
Components (9)
Processes (23)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 4 | 2 | 4 | 78.4 | |||||
myeloperoxidase measurement | 1 | 1 | 1 | 29.3 | |||||
body mass index | 2 | 1 | 2 | 8 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 4 | 78.4 | |||||
myeloperoxidase measurement | 1 | 29.3 | |||||
body mass index | 2 | 8 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | FK506 binding protein 1A | VGNC:14132 | 749347 | |||||
Mouse | MGI:95541 | 14225 | ||||||
Rat | RGD:2617 | 25639 | ||||||
Horse | FK506 binding protein 1A | 100629541 | ||||||
Cow | FK506 binding protein 1A | 614795 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | FK506 binding protein 1A | |||||
Mouse | ||||||
Rat | ||||||
Horse | FK506 binding protein 1A | |||||
Cow | FK506 binding protein 1A | |||||
Publication Statistics
PubMed Score 875.33
PubMed score by year
PubTator Score 88.76
PubTator score by year
Related Publications
Text Mined References (111)
GeneRif Annotations (43)
Items per page:
0 of 0
PMID | Year | Title |
|---|