FKBP1A
Peptidyl-prolyl cis-trans isomerase FKBP1A
Protein Classes
Protein Summary
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formati ...more
- ENST00000381719
- ENSP00000371138
- ENSG00000088832
- ENST00000400137
- ENSP00000383003
- FKBP1
- FKBP12
- FKBP1
- PKC12
- PKCI2
- FKBP12
- PPIASE
- FKBP-12
- FKBP-1A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
disease perturbation | 1 | ||
transcription factor perturbation | 1 | ||
kinase perturbation | 0.98 | ||
molecular function | 0.97 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 806.78 (req: < 5)
Gene RIFs: 43 (req: <= 3)
Antibodies: 377 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 806.78 (req: >= 5)
Gene RIFs: 43 (req: > 3)
Antibodies: 377 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 332
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 5
Approved Drugs (5)
1 – 5 of 5
Active Ligands (332)
1 – 10 of 332
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 2 | 1 | 2 | 18.1 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 2 | 18.1 | |||||
Protein Data Bank (49)
1 – 5 of 49
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (30)
Reactome (15)
PathwayCommons (11)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 15
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Calcineurin activates NFAT | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | Downstream signaling events of B Cell Receptor (BCR) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Calcineurin activates NFAT | ||||
Disease | ||||
Diseases of signal transduction | ||||
Downstream signaling events of B Cell Receptor (BCR) | ||||
Gene Ontology Terms (40)
Functions (8)
Components (9)
Processes (23)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Protein-Protein Interactions (206)
1 – 10 of 206
MTOR
Family: Kinase
Novelty: 0.00012333
Score: 0.999
Data Source: STRINGDB
TGFBR1
Family: Kinase
Novelty: 0.00081645
Score: 0.998
Data Source: Reactome,STRINGDB
PPP3R1
Novelty: 0.00263264
Score: 0.997
Data Source: STRINGDB
ACVR1
Family: Kinase
Novelty: 0.00284646
Score: 0.992
Data Source: STRINGDB
RYR1
Family: IC
Novelty: 0.00077827
Score: 0.985
Data Source: STRINGDB
PPP3CA
Family: Enzyme
Novelty: 0.00234189
Score: 0.976
Data Source: STRINGDB
ACVRL1
Family: Kinase
Novelty: 0.00310167
Score: 0.961
Data Source: STRINGDB
PIN1
Family: Enzyme
Novelty: 0.00957198
Score: 0.955
Data Source: STRINGDB
PPP3CB
Family: Enzyme
Novelty: 0.02156713
Score: 0.953
Data Source: STRINGDB
SMAD7
Family: TF
Novelty: 0.00116343
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score 806.78
PubMed score by year
PubTator Score 88.76
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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