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Tclin
PPIA
Peptidyl-prolyl cis-trans isomerase A

Protein Summary
Description
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355968
  • ENSP00000430817
  • ENSG00000196262
  • ENST00000468812
  • ENSP00000419425
  • ENST00000489459
  • ENSP00000427976
  • ENST00000620047
  • ENSP00000479961

Symbol
  • CYPA
  • CYPA
  • CYPH
  • HEL-S-69p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
virus perturbation
1
transcription factor binding site profile
0.97


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1047.7   (req: < 5)
Gene RIFs: 161   (req: <= 3)
Antibodies: 599   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1047.7   (req: >= 5)
Gene RIFs: 161   (req: > 3)
Antibodies: 599   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 135
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (135)
US9090657, DEBIO-025, 2
Rendered image for US9090657, DEBIO-025, 2
US9090657, Cyclosporine A, 1
Rendered image for US9090657, Cyclosporine A, 1
NIM258
Rendered image for NIM258
CHEMBL3344493
Rendered image for CHEMBL3344493
CHEMBL3752642
Rendered image for CHEMBL3752642
CHEMBL1688203
Rendered image for CHEMBL1688203
CHEMBL1269582
Rendered image for CHEMBL1269582
CHEMBL1269581
Rendered image for CHEMBL1269581
CHEMBL1269580
Rendered image for CHEMBL1269580
CHEMBL4092230
Rendered image for CHEMBL4092230
Protein-Protein Interactions (179)
PPP3CA
Tchem
Family:  Enzyme
Novelty:  0.00234189
Score:  0.997
Data Source:  STRINGDB
PPP3R1
Tbio
Novelty:  0.00263264
Score:  0.993
Data Source:  STRINGDB
BSG
Tbio
Novelty:  0.0010285
Score:  0.979
Data Source:  Reactome,STRINGDB
PPP3CB
Tbio
Family:  Enzyme
Novelty:  0.02156713
Score:  0.953
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.934
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.927
Data Source:  STRINGDB
NFATC1
Tchem
Family:  TF
Novelty:  0.00130337
Score:  0.919
Data Source:  STRINGDB
NFATC2
Tbio
Family:  TF
Novelty:  0.00312526
Score:  0.915
Data Source:  STRINGDB
CFL1
Tbio
Novelty:  0.00071544
Score:  0.914
Data Source:  STRINGDB
AIFM1
Tbio
Novelty:  0.00940088
Score:  0.914
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (73)
APOBEC3G mediated resistance to HIV-1 infection (R-HSA-180689)

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Find Similar Targets
Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APOBEC3G mediated resistance to HIV-1 infection
Reactome
Adaptive Immune System
Reactome
Assembly Of The HIV Virion
Reactome
Basigin interactions
Reactome
Binding and entry of HIV virion
Name
Explore in Pharos
Explore in Source
APOBEC3G mediated resistance to HIV-1 infection
Adaptive Immune System
Assembly Of The HIV Virion
Basigin interactions
Binding and entry of HIV virion
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (34)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
86.5
platelet count
3
3
3
86
intelligence
3
7
3
6
82.9
body mass index
3
2
3
78.4
self reported educational attainment
3
2
3
77.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
86.5
platelet count
3
86
intelligence
3
6
82.9
body mass index
3
78.4
self reported educational attainment
3
77.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
peptidylprolyl isomerase A
574102
Mouse
MGI:97749
268373
Rat
RGD:3372
25518
Dog
peptidylprolyl isomerase A (cyclophilin A) pseudogene
403581
Cow
peptidylprolyl isomerase A
281418
Species
Name
OMA
EggNOG
Inparanoid
Macaque
peptidylprolyl isomerase A
Mouse
Rat
Dog
peptidylprolyl isomerase A (cyclophilin A) pseudogene
Cow
peptidylprolyl isomerase A
Publication Statistics
PubMed Score 1047.70
PubMed score by year
PubTator Score 394.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title