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Tbio
RPL11
60S ribosomal protein L11

Protein Summary
Description
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:19061985, PubMed:12962325, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374550
  • ENSP00000363676
  • ENSG00000142676
  • ENST00000643754
  • ENSP00000496250

Symbol
  • L11
  • uL5
  • DBA7
  • GIG34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.96
kinase perturbation
0.96
hub protein
0.95
virus perturbation
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.94   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.94   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
1
1
62.1
1
1
0
1.2
56.8
mammographic density measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
62.1
0
1.2
56.8
mammographic density measurement
1
30.2
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L11
VGNC:1500
745599
Macaque
ribosomal protein L11
106996912
Mouse
MGI:1914275
67025
Rat
RGD:1308681
362631
Dog
ribosomal protein L11
VGNC:54771
100684296
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L11
Macaque
ribosomal protein L11
Mouse
Rat
Dog
ribosomal protein L11
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62913-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (37)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (33)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (642)
1 – 10 of 642
HIST2H2BF
Tdark
Novelty:  1.40321359
p_int:  0.999999956
p_ni:  4.1e-8
p_wrong:  3e-9
Data Source:  BioPlex
MDM4
Tchem
Novelty:  0.00321558
p_int:  0.999995436
p_ni:  0.000004558
p_wrong:  7e-9
Score:  0.493
Data Source:  BioPlex,STRINGDB
ZBTB10
Tbio
Family:  TF
Novelty:  0.05707286
p_int:  0.999986311
p_ni:  0.000013689
Data Source:  BioPlex
ZNF888
Tdark
p_int:  0.999908482
p_ni:  0.000020096
p_wrong:  0.000071422
Data Source:  BioPlex
SURF2
Tdark
Novelty:  0.10662558
p_int:  0.999850559
p_ni:  0.000148883
p_wrong:  5.59e-7
Score:  0.248
Data Source:  BioPlex,STRINGDB
HEATR3
Tbio
Novelty:  0.08367436
p_int:  0.999251159
p_ni:  0.000748841
Score:  0.267
Data Source:  BioPlex,STRINGDB
MDM2
Tchem
Family:  Enzyme
Novelty:  0.00028385
p_int:  0.998846003
p_ni:  0.001151638
p_wrong:  0.00000236
Score:  0.997
Data Source:  BioPlex,STRINGDB
RPL36AL
Tbio
Novelty:  0.09336423
p_int:  0.997849473
p_ni:  0.002150522
p_wrong:  5e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
ZNF724
Tdark
Family:  TF
Novelty:  21.16304348
p_int:  0.996236009
p_ni:  0.001754381
p_wrong:  0.002009611
Data Source:  BioPlex
GTPBP4
Tchem
Novelty:  0.00062563
p_int:  0.984747236
p_ni:  0.015252764
Score:  0.575
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  205.94

PubMed score by year
PubTator Score  84.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer