Tbio RPL10A 60S ribosomal protein L10a

Protein Summary

Description

Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P62906
• B2R801
• P52859
• P53025
• Q5TZT6
• Q8J013

Gene Name

• RPL10A

Ensembl ID

• ENST00000322203
• ENSP00000363018
• ENSG00000198755

Symbol

• NEDD6
• L10A
• CSA19
• NEDD6
• Csa-19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
kinase perturbation	1
transcription factor binding site profile	0.94
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 60s Ribosomal Protein L10a

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 60s Ribosomal Protein L10a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.51   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 219   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.51   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (481)

Explore Interacting Targets

1 – 10 of 481

• See Interactions on String-DB

HIST2H2BF

Tdark

Novelty:  1.40321359

p_int:  0.999999189

p_ni:  3.6e-8

p_wrong:  7.75e-7

Score:  0.832

Data Source:  BioPlex,STRINGDB

WDR89

Tdark

Novelty:  1.32691886

p_int:  0.999677283

p_ni:  0.000322712

p_wrong:  5e-9

Score:  0.536

Data Source:  BioPlex,STRINGDB

NOL8

Tbio

Novelty:  0.28065454

p_int:  0.998696856

p_ni:  0.001303144

Score:  0.536

Data Source:  BioPlex,STRINGDB

CNBP

Tbio

Novelty:  0.00404247

p_int:  0.980426661

p_ni:  0.019573339

Score:  0.329

Data Source:  BioPlex,STRINGDB

RPL37A

Tbio

Novelty:  0.03475061

p_int:  0.979464799

p_ni:  0.020535201

Score:  0.999

Data Source:  BioPlex,STRINGDB

SART3

Tbio

Novelty:  0.02353492

p_int:  0.964452468

p_ni:  0.035547532

Score:  0.158

Data Source:  BioPlex,STRINGDB

RPL30

Tbio

Novelty:  0.0134194

p_int:  0.957090638

p_ni:  0.042909362

Score:  0.999

Data Source:  BioPlex,STRINGDB

RPL36AL

Tbio

Novelty:  0.09336423

p_int:  0.955677091

p_ni:  0.044322908

p_wrong:  1e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

MAGEB10

Tdark

Novelty:  2.96156972

p_int:  0.95101195

p_ni:  0.04898805

Data Source:  BioPlex

ZCCHC7

Tbio

Novelty:  0.01655453

p_int:  0.948630495

p_ni:  0.051369505

Score:  0.546

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (34)

Reactome (32)

KEGG (1)

WikiPathways (1)

Axon guidance (R-HSA-422475)

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1 – 5 of 32

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Eukaryotic Translation Elongation	96 targets	R-HSA-156842

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Developmental Biology	1055 targets	R-HSA-1266738
Disease	1105 targets	R-HSA-1643685
Eukaryotic Translation Elongation	96 targets	R-HSA-156842

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (2)

Components (7)

Processes (6)

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1 – 2 of 2

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
structural constituent of ribosome	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (16)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 16

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted hip circumference	EFO_0008039	2	12	13		95.9
heel bone mineral density	EFO_0009270	2	4	5		85.3
platelet count	EFO_0004309	1	1	1		72.5
birth weight	EFO_0004344	2	2	2		68.2
body height	EFO_0004339	4	3	3	6.8	67.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 16

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted hip circumference	EFO_0008039	13		95.9
heel bone mineral density	EFO_0009270	5		85.3
platelet count	EFO_0004309	1		72.5
birth weight	EFO_0004344	2		68.2
body height	EFO_0004339	3	6.8	67.3

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Isopeptide bond
Phosphoprotein
Polymorphism
Reference proteome
Ribonucleoprotein
Ribosomal protein
Ubl conjugation

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
autoimmune thyroid disease
birth weight
BMI-adjusted hip circumference
BMI-adjusted waist circumference
body height
eosinophil count
eosinophil percentage of leukocytes
heel bone mineral density
insomnia measurement

IDG Resources

No IDG generated resources found

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ribosomal protein L10a	VGNC:3687	462637
Macaque	ribosomal protein L10a		718783
Mouse	ribosomal protein L10A	MGI:1343877	19896
Rat	ribosomal protein L10A	RGD:620497	81729
Dog	ribosomal protein L10a		474884

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ribosomal protein L10a
Macaque	ribosomal protein L10a
Mouse	ribosomal protein L10A
Rat	ribosomal protein L10A
Dog	ribosomal protein L10a

Publication Statistics

PubMed Score 58.51

PubMed score by year

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PubTator Score 11.49

PubTator score by year

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Related Publications

Text Mined References (27)

GeneRif Annotations (3)

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10

0 of 0

PMID	Year	Title