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Tbio
RPL10A
60S ribosomal protein L10a

Protein Summary
Description
Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322203
  • ENSP00000363018
  • ENSG00000198755

Symbol
  • NEDD6
  • L10A
  • CSA19
  • NEDD6
  • Csa-19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
transcription factor binding site profile
0.94
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.48   (req: < 5)
View Publications
Gene RIFs: 3   (req: <= 3)
View Gene RIFs
Antibodies: 219   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.48   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
533 targets
R-HSA-422475
Reactome
Cap-dependent Translation Initiation
121 targets
R-HSA-72737
Reactome
Developmental Biology
1055 targets
R-HSA-1266738
Reactome
Disease
1105 targets
R-HSA-1643685
Reactome
Eukaryotic Translation Elongation
96 targets
R-HSA-156842
Name
Explore in Pharos
Explore in Source
Axon guidance
533 targets
R-HSA-422475
Cap-dependent Translation Initiation
121 targets
R-HSA-72737
Developmental Biology
1055 targets
R-HSA-1266738
Disease
1105 targets
R-HSA-1643685
Eukaryotic Translation Elongation
96 targets
R-HSA-156842
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
RNA binding
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
structural constituent of ribosome
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (481)
1 – 10 of 481
HIST2H2BF
Tdark
Novelty: 1.95652174
p_int: 0.999999189
p_ni: 3.6e-8
p_wrong: 7.75e-7
Score: 0.832
Data Source: BioPlex,STRINGDB
WDR89
Tdark
p_int: 0.999677283
p_ni: 0.000322712
p_wrong: 5e-9
Score: 0.536
Data Source: BioPlex,STRINGDB
NOL8
Tbio
Novelty: 0.42182792
p_int: 0.998696856
p_ni: 0.001303144
Score: 0.536
Data Source: BioPlex,STRINGDB
CNBP
Tbio
Novelty: 0.0006668
p_int: 0.980426661
p_ni: 0.019573339
Score: 0.329
Data Source: BioPlex,STRINGDB
RPL37A
Tbio
Novelty: 0.03125092
p_int: 0.979464799
p_ni: 0.020535201
Score: 0.999
Data Source: BioPlex,STRINGDB
SART3
Tbio
Novelty: 0.02812047
p_int: 0.964452468
p_ni: 0.035547532
Score: 0.158
Data Source: BioPlex,STRINGDB
RPL30
Tbio
Novelty: 0.0256669
p_int: 0.957090638
p_ni: 0.042909362
Score: 0.999
Data Source: BioPlex,STRINGDB
RPL36AL
Tbio
Novelty: 0.15524221
p_int: 0.955677091
p_ni: 0.044322908
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
MAGEB10
Tdark
p_int: 0.95101195
p_ni: 0.04898805
Data Source: BioPlex
ZCCHC7
Tbio
Novelty: 0.01414427
p_int: 0.948630495
p_ni: 0.051369505
Score: 0.546
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  44.48

PubMed score by year
PubTator Score  11.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGD
1-70
QQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTH
70-140
NENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTM
140-210
GKPQRLY
210-217
MSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY