RPL31
60S ribosomal protein L31
Protein Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000264258
- ENSP00000264258
- ENSG00000071082
- ENST00000409028
- ENSP00000386717
- ENST00000409320
- ENSP00000387163
- ENST00000409733
- ENSP00000386681
- L31
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
disease perturbation | 0.99 | ||
transcription factor perturbation | 0.96 | ||
virus perturbation | 0.96 | ||
kinase perturbation | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.14 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 133 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.14 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 133 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (463)
RRS1
Novelty: 0.01643671
p_int: 0.909730305
p_ni: 0.090269695
Score: 0.551
Data Source: BioPlex,STRINGDB
RPL23A
Novelty: 0.02951947
p_int: 0.840355964
p_ni: 0.159644036
Score: 0.999
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (34)
Reactome (32)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Cap-dependent Translation Initiation | ||||
Reactome | Developmental Biology | ||||
Reactome | Disease | ||||
Reactome | Eukaryotic Translation Elongation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Cap-dependent Translation Initiation | ||||
Developmental Biology | ||||
Disease | ||||
Eukaryotic Translation Elongation | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (6)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 2 | 2 | 2 | 90.1 | |||||
myeloid white cell count | 1 | 1 | 1 | 78.3 | |||||
neutrophil percentage of leukocytes | 1 | 1 | 1 | 64.9 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 60.2 | |||||
serum gamma-glutamyl transferase measurement | 1 | 1 | 1 | 57.8 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 2 | 90.1 | |||||
myeloid white cell count | 1 | 78.3 | |||||
neutrophil percentage of leukocytes | 1 | 64.9 | |||||
lymphocyte percentage of leukocytes | 1 | 60.2 | |||||
serum gamma-glutamyl transferase measurement | 1 | 57.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (17)
1 – 5 of 17
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | 60S ribosomal protein L31 | 744983 | ||||||
Macaque | ribosomal protein L31 | 710744 | ||||||
Mouse | MGI:2149632 | 114641 | ||||||
Rat | RGD:621202 | 64298 | ||||||
Rat | ||||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | 60S ribosomal protein L31 | |||||
Macaque | ribosomal protein L31 | |||||
Mouse | ||||||
Rat | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 28.14
PubMed score by year
PubTator Score 31.55
PubTator score by year
Related Publications
Text Mined References (30)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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