Tbio RPL31 60S ribosomal protein L31

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 60S Ribosomal Protein L31

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 60S Ribosomal Protein L31

Protein Summary

Description

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P62899
• B7Z4K2
• D3DVJ4
• P12947
• Q53SQ5
• Q6IRZ0
• Q6LBJ6

Gene Name

• RPL31

Ensembl ID

• ENST00000264258
• ENSP00000264258
• ENSG00000071082
• ENST00000409028
• ENSP00000386717
• ENST00000409320
• ENSP00000387163
• ENST00000409733
• ENSP00000386681

Symbol

• L31

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
disease perturbation	0.99
transcription factor perturbation	0.96
virus perturbation	0.96
kinase perturbation	0.91

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.14   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 133   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.14   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2	2	2		90.1
myeloid white cell count	EFO_0007988	1	1	1		78.3
neutrophil percentage of leukocytes	EFO_0007990	1	1	1		64.9
lymphocyte percentage of leukocytes	EFO_0007993	1	1	1		60.2
serum gamma-glutamyl transferase measurement	EFO_0004532	1	1	1		57.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2		90.1
myeloid white cell count	EFO_0007988	1		78.3
neutrophil percentage of leukocytes	EFO_0007990	1		64.9
lymphocyte percentage of leukocytes	EFO_0007993	1		60.2
serum gamma-glutamyl transferase measurement	EFO_0004532	1		57.8

Reset Zoom  Beta Count   Odds Ratio

Orthologs (17)

1 – 5 of 17

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	60S ribosomal protein L31		744983
Macaque	ribosomal protein L31		710744
Mouse	ribosomal protein L31	MGI:2149632	114641
Rat	ribosomal protein L31	RGD:621202	64298
Rat	-

Species	Name	OMA	EggNOG	Inparanoid
Chimp	60S ribosomal protein L31
Macaque	ribosomal protein L31
Mouse	ribosomal protein L31
Rat	ribosomal protein L31
Rat	-

Protein Structure (6 Structures, 1 AlphaFold Model)

tutorial

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62899-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (34)

Reactome (32)

KEGG (1)

WikiPathways (1)

Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 32

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Eukaryotic Translation Elongation	96 targets	R-HSA-156842

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Cap-dependent Translation Initiation	121 targets	R-HSA-72737
Developmental Biology	1055 targets	R-HSA-1266738
Disease	1105 targets	R-HSA-1643685
Eukaryotic Translation Elongation	96 targets	R-HSA-156842

Gene Ontology Terms (13)

Functions (2)

Components (6)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
structural constituent of ribosome	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (463)

Explore Interacting Targets

1 – 10 of 463

• See Interactions on String-DB

RRS1

Tbio

Novelty:  0.01643671

p_int:  0.909730305

p_ni:  0.090269695

Score:  0.551

Data Source:  BioPlex,STRINGDB

RPL23A

Tbio

Novelty:  0.02951947

p_int:  0.840355964

p_ni:  0.159644036

Score:  0.999

Data Source:  BioPlex,STRINGDB

RPS7

Tbio

Novelty:  0.00745987

Score:  0.999

Data Source:  STRINGDB

RPL19

Tbio

Novelty:  0.00756385

Score:  0.999

Data Source:  STRINGDB

RPL27

Tbio

Novelty:  0.0157566

Score:  0.999

Data Source:  STRINGDB

UBA52

Tbio

Novelty:  0.01637744

Score:  0.999

Data Source:  STRINGDB

RPL23

Tbio

Novelty:  0.02741113

Score:  0.999

Data Source:  STRINGDB

RPL21

Tbio

Novelty:  0.01023355

Score:  0.999

Data Source:  STRINGDB

RPS15A

Tbio

Novelty:  0.03502821

Score:  0.999

Data Source:  STRINGDB

RPL10L

Tbio

Novelty:  0.22224997

Score:  0.999

Data Source:  STRINGDB

Publication Statistics

PubMed Score  28.14

PubMed score by year

Reset Zoom

PubTator Score  31.55

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Complete proteome
Phosphoprotein
Reference proteome
Ribonucleoprotein
Ribosomal protein

GWAS Trait Find Similar Targets

No Header	No Header
aspartate aminotransferase measurement
BMI-adjusted hip circumference
intraocular pressure measurement
leukocyte count
lymphocyte percentage of leukocytes
myeloid white cell count
neutrophil count
neutrophil percentage of leukocytes
reticulocyte count
self reported educational attainment

MGI Phenotype Find Similar Targets

No Header	No Header
endocrine/exocrine gland phenotype
limbs/digits/tail phenotype
nervous system phenotype
reproductive system phenotype