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Tbio
RPL31
60S ribosomal protein L31

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264258
  • ENSP00000264258
  • ENSG00000071082
  • ENST00000409028
  • ENSP00000386717
  • ENST00000409320
  • ENSP00000387163
  • ENST00000409733
  • ENSP00000386681

Symbol
  • L31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.99
transcription factor perturbation
0.96
virus perturbation
0.96
kinase perturbation
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.14   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.14   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
90.1
myeloid white cell count
1
1
1
78.3
neutrophil percentage of leukocytes
1
1
1
64.9
lymphocyte percentage of leukocytes
1
1
1
60.2
serum gamma-glutamyl transferase measurement
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
90.1
myeloid white cell count
1
78.3
neutrophil percentage of leukocytes
1
64.9
lymphocyte percentage of leukocytes
1
60.2
serum gamma-glutamyl transferase measurement
1
57.8
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
60S ribosomal protein L31
744983
Macaque
ribosomal protein L31
710744
Mouse
MGI:2149632
114641
Rat
RGD:621202
64298
Rat
Species
Name
OMA
EggNOG
Inparanoid
Chimp
60S ribosomal protein L31
Macaque
ribosomal protein L31
Mouse
Rat
Rat
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62899-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (463)
1 – 10 of 463
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.909730305
p_ni:  0.090269695
Score:  0.551
Data Source:  BioPlex,STRINGDB
RPL23A
Tbio
Novelty:  0.02951947
p_int:  0.840355964
p_ni:  0.159644036
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPS7
Tbio
Novelty:  0.00745987
Score:  0.999
Data Source:  STRINGDB
RPL19
Tbio
Novelty:  0.00756385
Score:  0.999
Data Source:  STRINGDB
RPL27
Tbio
Novelty:  0.0157566
Score:  0.999
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.999
Data Source:  STRINGDB
RPL23
Tbio
Novelty:  0.02741113
Score:  0.999
Data Source:  STRINGDB
RPL21
Tbio
Novelty:  0.01023355
Score:  0.999
Data Source:  STRINGDB
RPS15A
Tbio
Novelty:  0.03502821
Score:  0.999
Data Source:  STRINGDB
RPL10L
Tbio
Novelty:  0.22224997
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  28.14

PubMed score by year
PubTator Score  31.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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