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Tbio
RPL39
60S ribosomal protein L39

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the S39E family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein is the smallest, and one of the most basic, proteins of the ribosome. This gene is co-transcribed with the U69 small nucleolar RNA gene, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361575
  • ENSP00000355315
  • ENSG00000198918

Symbol
  • L39
  • RPL39P42
  • RPL39_23_1806
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
1
disease perturbation
0.95
kinase perturbation
0.95
biological process
0.81
histone modification site profile
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.14   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.14   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
33.1
reticulocyte count
1
1
1
31.4
reticulocyte measurement
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
33.1
reticulocyte count
1
31.4
reticulocyte measurement
1
28.1
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1914498
67248
Rat
RGD:3593
25347
Horse
ribosomal protein L39
100629452
Chicken
ribosomal protein L39
CGNC:49054
374132
Anole lizard
ribosomal protein L39
100558508
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
ribosomal protein L39
Chicken
ribosomal protein L39
Anole lizard
ribosomal protein L39
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62891-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (344)
1 – 10 of 344
RPL29
Tbio
Novelty:  0.0126026
Score:  0.999
Data Source:  STRINGDB
RPS18
Tbio
Novelty:  0.00688684
Score:  0.999
Data Source:  STRINGDB
RPS3A
Tbio
Novelty:  0.01009445
Score:  0.999
Data Source:  STRINGDB
RPL36A
Tbio
Novelty:  0.06115838
Score:  0.999
Data Source:  STRINGDB
RPS12
Tbio
Novelty:  0.00497802
Score:  0.999
Data Source:  STRINGDB
RPL10L
Tbio
Novelty:  0.22224997
Score:  0.999
Data Source:  STRINGDB
RPL38
Tbio
Novelty:  0.02694553
Score:  0.999
Data Source:  STRINGDB
RPS23
Tbio
Novelty:  0.01846154
Score:  0.999
Data Source:  STRINGDB
RPS29
Tbio
Novelty:  0.02619305
Score:  0.999
Data Source:  STRINGDB
RPL28
Tbio
Novelty:  0.03136035
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  32.14

PubMed score by year
PubTator Score  17.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer