Tbio GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

Protein Summary

Description

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P62879
• B3KPU1
• P11016
• P54312

Gene Name

• GNB2

Ensembl ID

• ENST00000303210
• ENSP00000305260
• ENSG00000172354
• ENST00000393924
• ENSP00000377501
• ENST00000393926
• ENSP00000377503
• ENST00000419828
• ENSP00000390543
• ENST00000427895
• ENSP00000400286

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.93
interacting protein	0.92
protein domain	0.92
disease perturbation	0.9
transcription factor binding site profile	0.87

Protein Classes

PANTHER Classes

Protein / Hydrolase / Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-2

Protein / Enzyme Modulator / G-protein / Heterotrimeric G-protein / Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-2

DTO Classes

Protein / Enzyme / Hydrolase / Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.23   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 172   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.23   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0