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Tbio
GNB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303210
  • ENSP00000305260
  • ENSG00000172354
  • ENST00000393924
  • ENSP00000377501
  • ENST00000393926
  • ENSP00000377503
  • ENST00000419828
  • ENSP00000390543
  • ENST00000427895
  • ENSP00000400286
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.93
interacting protein
0.92
protein domain
0.92
disease perturbation
0.9
transcription factor binding site profile
0.87


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.23   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.23   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (637)
GNG2
Tbio
Novelty:  0.04807242
p_int:  0.999998559
p_ni:  0.000001441
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
GNGT1
Tbio
Novelty:  0.05291961
p_int:  0.999996182
p_ni:  0.000003818
Score:  0.999
Data Source:  BioPlex,STRINGDB
P63092
Tbio
Novelty:  0.00284739
p_int:  0.999981194
p_ni:  0.000018806
Score:  0.962
Data Source:  BioPlex,Reactome,STRINGDB
GNAI3
Tbio
Novelty:  0.03484857
p_int:  0.999979578
p_ni:  0.000020422
Score:  0.99
Data Source:  BioPlex,STRINGDB
PDCL
Tbio
Novelty:  0.00317454
p_int:  0.999827779
p_ni:  0.000172221
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PFDN5
Tbio
Novelty:  0.07673574
p_int:  0.996168697
p_ni:  0.003831303
Score:  0.512
Data Source:  BioPlex,STRINGDB
GNA13
Tbio
Novelty:  0.04149138
p_int:  0.995439416
p_ni:  0.004560584
Score:  0.959
Data Source:  BioPlex,STRINGDB
SLC6A5
Tchem
Family:  Transporter
Novelty:  0.00387587
p_int:  0.99535307
p_ni:  0.00464693
Data Source:  BioPlex
NTRK3
Tclin
Family:  Kinase
Novelty:  0.00177321
p_int:  0.994610679
p_ni:  0.005389321
p_wrong:  1e-9
Score:  0.18
Data Source:  BioPlex,STRINGDB
DEFB104A
Tbio
Novelty:  0.0468791
p_int:  0.991422693
p_ni:  0.008577307
Data Source:  BioPlex
Nearest Tclin Targets (26)
Explore Nearest Tclin Targets
1 – 5 of 16
F2R
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CHRM1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CHRM2
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CNR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
GABBR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
Pathways (113)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 59
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Activation of kainate receptors upon glutamate binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Activation of kainate receptors upon glutamate binding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (44)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
8
7
8
99.5
erythrocyte count
9
6
11
99.4
hematocrit
11
13
20
99.3
hemoglobin measurement
6
11
17
99.1
mean corpuscular volume
5
7
7
97.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
8
99.5
erythrocyte count
11
99.4
hematocrit
20
99.3
hemoglobin measurement
17
99.1
mean corpuscular volume
7
97.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit beta 2
VGNC:8684
739897
Mouse
MGI:95784
14693
Rat
RGD:69319
81667
Horse
G protein subunit beta 2
VGNC:18425
100067486
Cow
G protein subunit beta 2
VGNC:29459
281202
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit beta 2
Mouse
Rat
Horse
G protein subunit beta 2
Cow
G protein subunit beta 2
Publication Statistics
PubMed Score 16.23
PubMed score by year
PubTator Score 4.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title